The alpha chemokine Interferon gamma-induced protein 10 (IP-10) and its receptor, CXC receptor 3, appear to contribute to the pathogenesis of Graves' disease (GD) and Graves' ophthalmopathy (GO). Under the influence of Interferon-γ, IP-10 is secreted by thyrocytes (in GD), fibroblasts and preadipocytes (in GO). Determination of high level of IP-10 in peripheral liquids is therefore a marker of a Th1 orientated immune response. Circulating IP-10 is associated with the active phase of GD in both newly diagnosed and relapsing hyperthyroid patients. Methimazole reduces IP-10 secretion by isolated thyrocytes, decreases serum IP-10 levels, and promotes a transition from Th1 to Th2 dominance in patients in GD active phase. In GD patients the decrease of IP-10 after thyroidectomy and radioiodine strongly suggests that this chemokine is mainly produced by the thyroid itself. In GO patients the increased concentrations of IP-10, at least in part, reflect the activity of orbital inflammation. A significant reductions in IP-10 serum concentrations during corticosteroids and or radiotherapy treatments, as compared both to control group and to basal values in GO patients, suggest that this chemokine could serve as a guideline in therapeutic decision-making in patients with GO. Further studies are needed to evaluate whether IP-10 is a novel therapeutic target in GD and GO.
[The alpha chemokine "Interferon gamma-induced protein 10" (IP-10) in Graves' disease] / Mancusi, C; Di Domenicantonio, A; Politti, U; Giuggioli, D; Antonelli, A; Ferri, Clodoveo; Fallahi, P.. - In: LA CLINICA TERAPEUTICA. - ISSN 1972-6007. - ELETTRONICO. - 165:(2014), pp. e174-180. [10.7471/CT.2014.1705]
Data di pubblicazione: | 2014 | |
Titolo: | [The alpha chemokine "Interferon gamma-induced protein 10" (IP-10) in Graves' disease] | |
Autore/i: | Mancusi, C; Di Domenicantonio, A; Politti, U; Giuggioli, D; Antonelli, A; Ferri, Clodoveo; Fallahi, P. | |
Autore/i UNIMORE: | ||
Digital Object Identifier (DOI): | http://dx.doi.org/10.7471/CT.2014.1705 | |
Rivista: | ||
Volume: | 165 | |
Pagina iniziale: | e174 | |
Pagina finale: | 180 | |
Codice identificativo Scopus: | 2-s2.0-84899721348 | |
Codice identificativo Pubmed: | 24770830 | |
Citazione: | [The alpha chemokine "Interferon gamma-induced protein 10" (IP-10) in Graves' disease] / Mancusi, C; Di Domenicantonio, A; Politti, U; Giuggioli, D; Antonelli, A; Ferri, Clodoveo; Fallahi, P.. - In: LA CLINICA TERAPEUTICA. - ISSN 1972-6007. - ELETTRONICO. - 165:(2014), pp. e174-180. [10.7471/CT.2014.1705] | |
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