[The alpha chemokine "Interferon gamma-induced protein 10" (IP-10) in Graves' disease]

Mancusi, C; Di Domenicantonio, A; Politti, U; Giuggioli, D; Antonelli, A; Ferri, Clodoveo; Fallahi, P.

doi:10.7471/CT.2014.1705

The alpha chemokine Interferon gamma-induced protein 10 (IP-10) and its receptor, CXC receptor 3, appear to contribute to the pathogenesis of Graves' disease (GD) and Graves' ophthalmopathy (GO). Under the influence of Interferon-γ, IP-10 is secreted by thyrocytes (in GD), fibroblasts and preadipocytes (in GO). Determination of high level of IP-10 in peripheral liquids is therefore a marker of a Th1 orientated immune response. Circulating IP-10 is associated with the active phase of GD in both newly diagnosed and relapsing hyperthyroid patients. Methimazole reduces IP-10 secretion by isolated thyrocytes, decreases serum IP-10 levels, and promotes a transition from Th1 to Th2 dominance in patients in GD active phase. In GD patients the decrease of IP-10 after thyroidectomy and radioiodine strongly suggests that this chemokine is mainly produced by the thyroid itself. In GO patients the increased concentrations of IP-10, at least in part, reflect the activity of orbital inflammation. A significant reductions in IP-10 serum concentrations during corticosteroids and or radiotherapy treatments, as compared both to control group and to basal values in GO patients, suggest that this chemokine could serve as a guideline in therapeutic decision-making in patients with GO. Further studies are needed to evaluate whether IP-10 is a novel therapeutic target in GD and GO.

[The alpha chemokine "Interferon gamma-induced protein 10" (IP-10) in Graves' disease] / Mancusi, C; Di Domenicantonio, A; Politti, U; Giuggioli, D; Antonelli, A; Ferri, Clodoveo; Fallahi, P.. - In: LA CLINICA TERAPEUTICA. - ISSN 1972-6007. - ELETTRONICO. - 165:(2014), pp. e174-180. [10.7471/CT.2014.1705]

Data di pubblicazione:	2014
Titolo:	[The alpha chemokine "Interferon gamma-induced protein 10" (IP-10) in Graves' disease]
Autore/i:	Mancusi, C; Di Domenicantonio, A; Politti, U; Giuggioli, D; Antonelli, A; Ferri, Clodoveo; Fallahi, P.
Autore/i UNIMORE:	Mancusi, C Di Domenicantonio, A Politti, U GIUGGIOLI, DILIA Antonelli, A FERRI, Clodoveo Fallahi, P. mostra contributor esterni nascondi contributor esterni
Digital Object Identifier (DOI):	http://dx.doi.org/10.7471/CT.2014.1705
Rivista:	LA CLINICA TERAPEUTICA
Volume:	165
Pagina iniziale:	e174
Pagina finale:	180
Codice identificativo Scopus:	2-s2.0-84899721348
Codice identificativo Pubmed:	24770830
Citazione:	[The alpha chemokine "Interferon gamma-induced protein 10" (IP-10) in Graves' disease] / Mancusi, C; Di Domenicantonio, A; Politti, U; Giuggioli, D; Antonelli, A; Ferri, Clodoveo; Fallahi, P.. - In: LA CLINICA TERAPEUTICA. - ISSN 1972-6007. - ELETTRONICO. - 165:(2014), pp. e174-180. [10.7471/CT.2014.1705]
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