In previous studies, the present group showed that a factor, present in the cerebrospinal fluid of seven neuro-patients, was capable of inducing cell damages on cell cultures of epithelial cells (Vero), glial cells (DG54-MG) and human primary lymphocytes. The cytotoxicity, once induced, could be transmitted to fresh cell cultures using crude preparations obtained from the cytotoxic cell cultures.
Electron microscope study on a transmissible cytotoxic factor isolated from cerebrospinal fluid of neurological patients: analysis of its structure and of its effects on various types of cell cultures / Guerra, Deanna; Ronchetti, Ivonne; Beretti, Francesca; Bartoletti, Anna Maria; Pietrosemoli, Paola; Gelormini, M. S; Malagolini, N; Muscatello, Umberto; Portolani, Marinella. - In: JOURNAL OF CLINICAL PATHOLOGY. - ISSN 0021-9746. - STAMPA. - 65:(2012), pp. 20-28. [10.1136/jclinpath-2011-200034]