Non-alcoholic fatty liver disease, one of the most prevalent liver disorders in Western countries, is characterized by hepatic accumulation of triglycerides. Bile acids have long been known to affect triglyceride homeostasis through a not completely understood mechanism.

Effects of bile duct ligation and cholic acid treatment on fatty liver in two rat models of non-alcoholic fatty liver disease / Gabbi, C., Bertolotti, M., Anzivino, C., Macchioni, D., Del Puppo, M., Ricchi, M., Carubbi, F., Tagliafico, E., Romagnoli, D., Odoardi, M.R., Loria, P., Losi, L., Carulli, N.. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - STAMPA. - 44:12(2012), pp. 1018-1026. [10.1016/j.dld.2012.07.001]

Effects of bile duct ligation and cholic acid treatment on fatty liver in two rat models of non-alcoholic fatty liver disease

GABBI, Chiara;BERTOLOTTI, Marco;MACCHIONI, Daria;RICCHI, Matteo;CARUBBI, Francesca;TAGLIAFICO, Enrico;ROMAGNOLI, Dante;ODOARDI, Maria Rosaria;LORIA, Paola;CARULLI, Nicola
2012

Abstract

Non-alcoholic fatty liver disease, one of the most prevalent liver disorders in Western countries, is characterized by hepatic accumulation of triglycerides. Bile acids have long been known to affect triglyceride homeostasis through a not completely understood mechanism.
2012
no
Inglese
44
12
1018
1026
WOS:000311921400010
2-s2.0-84868301821
22883218
Animals; Biological Markers; Cholesterol 7-alpha-Hydroxylase; Cholic Acid; Common Bile Duct; Diet, High-Fat; Disease Models, Animal; Fatty Liver; Gas Chromatography-Mass Spectrometry; Hydroxycholesterols; Ligation; Liver; Male; Non-alcoholic Fatty Liver Disease; Orphan Nuclear Receptors; Random Allocation; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Receptors, Cytoplasmic and Nuclear; Treatment Outcome; Dietary Supplements
Experiments performed in two different animal models to study the effect of cholic acid in fatty liver disease.Data indicate that pharmacological approaches increasing the expression of CYP7A1 or stimulating farnesoid X receptor pathway, bile acis, could represent a promising treatment for non-alcoholic fatty liver disease.
reserved
info:eu-repo/semantics/article
Contributo su RIVISTA::Articolo su rivista
262
Effects of bile duct ligation and cholic acid treatment on fatty liver in two rat models of non-alcoholic fatty liver disease / Gabbi, C., Bertolotti, M., Anzivino, C., Macchioni, D., Del Puppo, M., Ricchi, M., Carubbi, F., Tagliafico, E., Romagnoli, D., Odoardi, M.R., Loria, P., Losi, L., Carulli, N.. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - STAMPA. - 44:12(2012), pp. 1018-1026. [10.1016/j.dld.2012.07.001]
Gabbi, Chiara; Bertolotti, Marco; Anzivino, Claudia; Macchioni, Daria; Del Puppo, Marina; Ricchi, Matteo; Carubbi, Francesca; Tagliafico, Enrico; Roma...espandi
13
File in questo prodotto:
File Dimensione Formato  
Gabbi-C._Effects-of-bile-duct-ligation-and-cholic-acid-treatment-on-fatty-liver-in-two-rat-models-of-non-alcoholic-fatty-liver-disease_2012.pdf

Accesso riservato

Descrizione: articolo principale
Tipologia: VOR - Versione pubblicata dall'editore
Dimensione 1.42 MB
Formato Adobe PDF
  Visualizza/Apri   Richiedi una copia
1.42 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1063468
Citazioni
  • ???jsp.display-item.citation.pmc??? 11
  • Scopus 21
  • ???jsp.display-item.citation.isi??? 20
social impact