G protein-coupled receptors (GPCRs) represent one of the largest families of transmembrane receptors and the most common drug target. The Adhesion subfamily is the second largest one of GPCRs and its several members are known to mediate neural development and immune system functioning through cell-cell and cell-matrix interactions. The distribution of these receptors has not been characterized in detail in the gastrointestinal (GI) tract. Here we present the first comprehensive anatomical profiling of mRNA expression of all 30 Adhesion GPCRs in the rat GI tract divided into twelve subsegments.
Adhesion GPCRs are widely expressed throughout the subsections of the gastrointestinal tract / Badiali, Luca; Cedernaes, Jonathan; Olszewski, Pawel K; Nylander, Olof; Vergoni, Anna Valeria; Schiöth, Helgi B.. - In: BMC GASTROENTEROLOGY. - ISSN 1471-230X. - STAMPA. - 12:(2012), pp. 134-144. [10.1186/1471-230X-12-134]
Adhesion GPCRs are widely expressed throughout the subsections of the gastrointestinal tract
VERGONI, Anna Valeria;
2012
Abstract
G protein-coupled receptors (GPCRs) represent one of the largest families of transmembrane receptors and the most common drug target. The Adhesion subfamily is the second largest one of GPCRs and its several members are known to mediate neural development and immune system functioning through cell-cell and cell-matrix interactions. The distribution of these receptors has not been characterized in detail in the gastrointestinal (GI) tract. Here we present the first comprehensive anatomical profiling of mRNA expression of all 30 Adhesion GPCRs in the rat GI tract divided into twelve subsegments.
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