Selective halogenation of hyaluronan and partial halogen substitution by methotrexate led to 6-chloro-6-deoxy-6-O-methotrexylhyaluronan, a potential antitumor drug. The remaining halogen could be further substituted by a second organic carboxylate, leading to mixed esters. 6-O-Acetyl-6-O-methotrexylhyaluronan and 6-O-butyryl-6-O-methotrexylhyaluronan were thus synthesized and characterized by NMR spectroscopy.

Synthesis of 6-O-methotrexylhyaluronan as a drug delivery system / Sorbi, Claudia; Bergamin, Massimo; Bosi, Susanna; Dinon, Francesca; Aroulmoji, Vincent; Khan, Riaz; Murano, Erminio; Norbedo, Stefano. - In: CARBOHYDRATE RESEARCH. - ISSN 0008-6215. - STAMPA. - 344:(2009), pp. 91-97. [10.1016/j.carres.2008.09.021]

Synthesis of 6-O-methotrexylhyaluronan as a drug delivery system

SORBI, Claudia;
2009

Abstract

Selective halogenation of hyaluronan and partial halogen substitution by methotrexate led to 6-chloro-6-deoxy-6-O-methotrexylhyaluronan, a potential antitumor drug. The remaining halogen could be further substituted by a second organic carboxylate, leading to mixed esters. 6-O-Acetyl-6-O-methotrexylhyaluronan and 6-O-butyryl-6-O-methotrexylhyaluronan were thus synthesized and characterized by NMR spectroscopy.
2009
344
91
97
Synthesis of 6-O-methotrexylhyaluronan as a drug delivery system / Sorbi, Claudia; Bergamin, Massimo; Bosi, Susanna; Dinon, Francesca; Aroulmoji, Vincent; Khan, Riaz; Murano, Erminio; Norbedo, Stefano. - In: CARBOHYDRATE RESEARCH. - ISSN 0008-6215. - STAMPA. - 344:(2009), pp. 91-97. [10.1016/j.carres.2008.09.021]
Sorbi, Claudia; Bergamin, Massimo; Bosi, Susanna; Dinon, Francesca; Aroulmoji, Vincent; Khan, Riaz; Murano, Erminio; Norbedo, Stefano
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1063007
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