Transcriptional activation and cell cycle block are the keys for 5-fluorouracil induced up-regulation of human thymidylate synthase expression

Ligabue, Alessio; Marverti, Gaetano; Liebl, Ursula; Myllykallio, Hannu

doi:10.1371/journal.pone.0047318

5-fluorouracil, a commonly used chemotherapeutic agent, up-regulates expression of human thymidylate synthase (hTS). Several different regulatory mechanisms have been proposed to mediate this up-regulation in distinct cell lines, but their specific contributions in a single cell line have not been investigated to date. We have established the relative contributions of these previously proposed regulatory mechanisms in the ovarian cancer cell line 2008 and the corresponding cisplatin-resistant and 5-FU cross-resistant-subline C13*.

Transcriptional activation and cell cycle block are the keys for 5-fluorouracil induced up-regulation of human thymidylate synthase expression / Ligabue, Alessio; Marverti, Gaetano; Liebl, Ursula; Myllykallio, Hannu. - In: PLOS ONE. - ISSN 1932-6203. - STAMPA. - 7(2012), pp. e47318-e47318.

Data di pubblicazione:	2012
Titolo:	Transcriptional activation and cell cycle block are the keys for 5-fluorouracil induced up-regulation of human thymidylate synthase expression
Autore/i:	Ligabue, Alessio; Marverti, Gaetano; Liebl, Ursula; Myllykallio, Hannu
Autore/i UNIMORE:	LIGABUE, Alessio MARVERTI, Gaetano Liebl, Ursula Myllykallio, Hannu mostra contributor esterni nascondi contributor esterni
Digital Object Identifier (DOI):	http://dx.doi.org/10.1371/journal.pone.0047318
Rivista:	PLOS ONE
Volume:	7
Pagina iniziale:	e47318
Pagina finale:	e47318
Codice identificativo ISI:	WOS:000309889400074
Codice identificativo Scopus:	2-s2.0-84867304928
Codice identificativo Pubmed:	23056627
Citazione:	Transcriptional activation and cell cycle block are the keys for 5-fluorouracil induced up-regulation of human thymidylate synthase expression / Ligabue, Alessio; Marverti, Gaetano; Liebl, Ursula; Myllykallio, Hannu. - In: PLOS ONE. - ISSN 1932-6203. - STAMPA. - 7(2012), pp. e47318-e47318.
Tipologia	Articolo su rivista

File in questo prodotto:

File	Descrizione	Tipologia
PLOSone2012-journal.pone.0047318.pdf	Articolo principale	Versione dell'editore (versione pubblicata)	Open Access Visualizza/Apri

Utilizza questo identificativo per citare o creare un link a questo documento:
http://hdl.handle.net/11380/1062942

Citazioni

I documenti presenti in Iris Unimore sono rilasciati con licenza Creative Commons Attribuzione - Non commerciale - Non opere derivate 3.0 Italia, salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris