In this study, a detailed chemical characterization of Cedrelopsis grevei H. Baillon (Ptaeroxylaceae family) bark essential oil was perfomed. The GC analysis revealed a peculiar composition in terms of sesquiterpenes. The major components were found to be ishwarane, β-elemene, α-copaene, calamenene, β-selinene, γ-muurolene, α-muurolene and β-pinene. In addition to semi-quantification data, essential oil quantification was performed by means of the experimental and predicted relative response factors (RRF), using methyl octanoate as the internal standard. In vitro biological activity of C. grevei essential oil and its main isolated compounds (including ishwarane, β-elemene and α-copaene) was assayed for cytotoxic activity on human colon cancer cells CaCo-2 and human lung carcinoma cells A549 by means of the MTT assay. Furthermore, by combining the three main compounds, it was possible to evaluate the potential synergic effects. The results showed that the C. grevei essential oil exhibited interesting cytotoxic activity on both cancer cell lines.

Chemical composition and cytotoxic activity of Cedrelopsis grevei H. Baillon essential oil on human cancer cells / Tardugno, Roberta; Pellati, Federica; Antonella, Spagnoletti; Gianni, Sacchetti; Benvenuti, Stefania. - STAMPA. - Fall 2014:(2014), pp. 63-63. ((Intervento presentato al convegno Nutritional Analysis General Papers of the Division of Agricultural and Food Chemistry, 248th American Chemical Society National Meeting & Exposition tenutosi a San Francisco (CA), USA nel 10-14 Agosto 2014.

Chemical composition and cytotoxic activity of Cedrelopsis grevei H. Baillon essential oil on human cancer cells

TARDUGNO, ROBERTA;PELLATI, Federica;BENVENUTI, Stefania
2014

Abstract

In this study, a detailed chemical characterization of Cedrelopsis grevei H. Baillon (Ptaeroxylaceae family) bark essential oil was perfomed. The GC analysis revealed a peculiar composition in terms of sesquiterpenes. The major components were found to be ishwarane, β-elemene, α-copaene, calamenene, β-selinene, γ-muurolene, α-muurolene and β-pinene. In addition to semi-quantification data, essential oil quantification was performed by means of the experimental and predicted relative response factors (RRF), using methyl octanoate as the internal standard. In vitro biological activity of C. grevei essential oil and its main isolated compounds (including ishwarane, β-elemene and α-copaene) was assayed for cytotoxic activity on human colon cancer cells CaCo-2 and human lung carcinoma cells A549 by means of the MTT assay. Furthermore, by combining the three main compounds, it was possible to evaluate the potential synergic effects. The results showed that the C. grevei essential oil exhibited interesting cytotoxic activity on both cancer cell lines.
Nutritional Analysis General Papers of the Division of Agricultural and Food Chemistry, 248th American Chemical Society National Meeting & Exposition
San Francisco (CA), USA
10-14 Agosto 2014
Tardugno, Roberta; Pellati, Federica; Antonella, Spagnoletti; Gianni, Sacchetti; Benvenuti, Stefania
Chemical composition and cytotoxic activity of Cedrelopsis grevei H. Baillon essential oil on human cancer cells / Tardugno, Roberta; Pellati, Federica; Antonella, Spagnoletti; Gianni, Sacchetti; Benvenuti, Stefania. - STAMPA. - Fall 2014:(2014), pp. 63-63. ((Intervento presentato al convegno Nutritional Analysis General Papers of the Division of Agricultural and Food Chemistry, 248th American Chemical Society National Meeting & Exposition tenutosi a San Francisco (CA), USA nel 10-14 Agosto 2014.
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/1062703
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? 0
social impact