Here, we investigate the in vitro biocompatibility of polyvinylidenefluoride (PVDF)–polytrifluoroethylene (PTrFE) copolymer thin films using neuronal cells. The aim is to obtain an optimal capping layer material for hybrid bio-organic electronic transducers based on organic electronic devices, which can be applied for bidirectional communication with the central nervous system. PVDF:PTrFE thin films were grown by spin coating and characterized by AFM. Human neuroblastoma SHSY5Y cells were used as neuronal model and their interaction with PVDF:PTrFE films was investigated in term of cell adhesion, proliferation, differentiation, and cytoskeleton organization. We show that PVDF:PTrFE thin films allowed standard SHSY5Y proliferation and neuronal differentiation, even if with reduced short-term cell adhesion and spreading.

Human Neuronal SHSY5Y Cells on PVDF:PTrFE Copolymer Thin Films / Tonazzini, Ilaria; Bystrenova, Eva; Chelli, Beatrice; Greco, Pierpaolo; De Leeuw, Dago; Biscarini, Fabio. - In: ADVANCED ENGINEERING MATERIALS. - ISSN 1527-2648. - STAMPA. - n/a(2015), pp. N/A-n/a. [10.1002/adem.201400441]

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