Background. Carcinoids enter the differential diagnosis of the solitary pulmonary nodule. Bronchial carcinoids have been traditionally considered as FDG-PET negative but recent studies have found an higher sensitivity of integrated FDG-PET/CT for the detection of these neoplasms. The purpose of this study was to investigate the value of integrated FDG-PET/CT for the evaluation of SPN suspected to be carcinoids. Methods. All patients with pathologically proven bronchial carcinoids who had FDG-PET/CT scans between 2006 and 2012 have been retrospectively reviewed. PET/CT was performed with the same scanner and the same technique for all patients. The following data were retrieved: age, sex CT findings (side, location, size, shape, margins), SUVmax, type of operation, pathological findings (size and number of mitoses). Regarding PET findings, only SUVmax was considered, whereas the visual assessment was not undertaken. Carcinoids were defined as typical and atypical and as central and peripheral. The long-term follow-up was also recorded. The SUVmax was compared with the other clinical, radiological and pathological variables to find any significant difference or correlation. Results. Twenty-five patients were retrieved, 24 typical and one atypical carcinoid, 21 peripheral and 4 central lesions. The mean diameter on CT-scan was 25.3mm and the clinical size correlated well with the pathological size. Fifty-six percent of the tumors were ovoid and 68% had smooth margins. The mean SUVmax was 3.6 (range 1.4-12.9). All the lesions were completely resected. The regression analysis showed a direct correlation between the SUVmax and the tumor size (p=0.004). No further correlations were found between the SUVmax and the other variables. None of the patients had recurrent disease or died during the follow-up. Conclusions. Our study showed that FDG-PET/CT might be a useful tool in the evaluation of SPNs suspected to be bronchial carcinoids. When a solitary pulmonary nodule shows an ovoid/round shape and smooth margins on the CT scan and demonstrates an FDG uptake higher than that of the normal lung and with a SUVmax value >1-1.5, a carcinoid should be suspected. If benign lesions can be presumably excluded, surgical resection or at least a biopsy of the lesion is recommended.

Integrated FDG-PET/CT imaging is useful in the apporach to carcinoid tumors of the lung / Stefani, Alessandro; Franceschetto, Antonella; Nesci, Jessica; Aramini, Beatrice; Proli, Chiara; Kaleci, Shaniko; Casolo, Alessandra; Massi, Lucia; Casali, Christian; Morandi, Uliano. - In: JOURNAL OF CARDIOTHORACIC SURGERY. - ISSN 1749-8090. - ELETTRONICO. - 8:1(2013), pp. 1-7. [10.1186/1749-8090-8-223]

Integrated FDG-PET/CT imaging is useful in the apporach to carcinoid tumors of the lung

STEFANI, Alessandro;FRANCESCHETTO, Antonella;Nesci, Jessica;Aramini, Beatrice;KALECI, SHANIKO;MORANDI, Uliano
2013

Abstract

Background. Carcinoids enter the differential diagnosis of the solitary pulmonary nodule. Bronchial carcinoids have been traditionally considered as FDG-PET negative but recent studies have found an higher sensitivity of integrated FDG-PET/CT for the detection of these neoplasms. The purpose of this study was to investigate the value of integrated FDG-PET/CT for the evaluation of SPN suspected to be carcinoids. Methods. All patients with pathologically proven bronchial carcinoids who had FDG-PET/CT scans between 2006 and 2012 have been retrospectively reviewed. PET/CT was performed with the same scanner and the same technique for all patients. The following data were retrieved: age, sex CT findings (side, location, size, shape, margins), SUVmax, type of operation, pathological findings (size and number of mitoses). Regarding PET findings, only SUVmax was considered, whereas the visual assessment was not undertaken. Carcinoids were defined as typical and atypical and as central and peripheral. The long-term follow-up was also recorded. The SUVmax was compared with the other clinical, radiological and pathological variables to find any significant difference or correlation. Results. Twenty-five patients were retrieved, 24 typical and one atypical carcinoid, 21 peripheral and 4 central lesions. The mean diameter on CT-scan was 25.3mm and the clinical size correlated well with the pathological size. Fifty-six percent of the tumors were ovoid and 68% had smooth margins. The mean SUVmax was 3.6 (range 1.4-12.9). All the lesions were completely resected. The regression analysis showed a direct correlation between the SUVmax and the tumor size (p=0.004). No further correlations were found between the SUVmax and the other variables. None of the patients had recurrent disease or died during the follow-up. Conclusions. Our study showed that FDG-PET/CT might be a useful tool in the evaluation of SPNs suspected to be bronchial carcinoids. When a solitary pulmonary nodule shows an ovoid/round shape and smooth margins on the CT scan and demonstrates an FDG uptake higher than that of the normal lung and with a SUVmax value >1-1.5, a carcinoid should be suspected. If benign lesions can be presumably excluded, surgical resection or at least a biopsy of the lesion is recommended.
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Integrated FDG-PET/CT imaging is useful in the apporach to carcinoid tumors of the lung / Stefani, Alessandro; Franceschetto, Antonella; Nesci, Jessica; Aramini, Beatrice; Proli, Chiara; Kaleci, Shaniko; Casolo, Alessandra; Massi, Lucia; Casali, Christian; Morandi, Uliano. - In: JOURNAL OF CARDIOTHORACIC SURGERY. - ISSN 1749-8090. - ELETTRONICO. - 8:1(2013), pp. 1-7. [10.1186/1749-8090-8-223]
Stefani, Alessandro; Franceschetto, Antonella; Nesci, Jessica; Aramini, Beatrice; Proli, Chiara; Kaleci, Shaniko; Casolo, Alessandra; Massi, Lucia; Casali, Christian; Morandi, Uliano
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/1061812
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