Patients with breast cancer are classified as having cells that over-express the human epidermal growth factor receptor 2 (known as HER2-positive) or not (HER2-negative). Typically, patients with HER2-positive disease have a worse prognosis. Trastuzumab is a selective treatment that targets the HER2 pathway. The available evidence supporting trastuzumab regimens mostly relies upon surrogate endpoints and, although the efficacy results seem to support its use, other uncertainties have been raised about its net benefit in relation to transient cardiac toxicity and a long-term increased risk of metastasis to the central nervous system.

Trastuzumab-containing regimens for metastatic breast cancer / Balduzzi, Sara; Mantarro, Stefania; Guarneri, Valentina; Tagliabue, Ludovica; Pistotti, Vanna; Moja, Lorenzo; D'Amico, Roberto. - In: COCHRANE DATABASE OF SYSTEMATIC REVIEWS. - ISSN 1469-493X. - STAMPA. - 2014:6(2014), pp. CD006242-CD006242. [10.1002/14651858.CD006242.pub2]

Trastuzumab-containing regimens for metastatic breast cancer

BALDUZZI, Sara;GUARNERI, Valentina;D'AMICO, Roberto
2014

Abstract

Patients with breast cancer are classified as having cells that over-express the human epidermal growth factor receptor 2 (known as HER2-positive) or not (HER2-negative). Typically, patients with HER2-positive disease have a worse prognosis. Trastuzumab is a selective treatment that targets the HER2 pathway. The available evidence supporting trastuzumab regimens mostly relies upon surrogate endpoints and, although the efficacy results seem to support its use, other uncertainties have been raised about its net benefit in relation to transient cardiac toxicity and a long-term increased risk of metastasis to the central nervous system.
2014
2014
6
CD006242
CD006242
Trastuzumab-containing regimens for metastatic breast cancer / Balduzzi, Sara; Mantarro, Stefania; Guarneri, Valentina; Tagliabue, Ludovica; Pistotti, Vanna; Moja, Lorenzo; D'Amico, Roberto. - In: COCHRANE DATABASE OF SYSTEMATIC REVIEWS. - ISSN 1469-493X. - STAMPA. - 2014:6(2014), pp. CD006242-CD006242. [10.1002/14651858.CD006242.pub2]
Balduzzi, Sara; Mantarro, Stefania; Guarneri, Valentina; Tagliabue, Ludovica; Pistotti, Vanna; Moja, Lorenzo; D'Amico, Roberto
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1061506
Citazioni
  • ???jsp.display-item.citation.pmc??? 83
  • Scopus 96
  • ???jsp.display-item.citation.isi??? 151
social impact