β-Blocker therapy may control heart rate and attenuate the deleterious effects of β-adrenergic receptor stimulation in septic shock. However, β-Blockers are not traditionally used for this condition and may worsen cardiovascular decompensation related through negative inotropic and hypotensive effects.
Effect of heart rate control with esmolol on hemodynamic and clinical outcomes in patients with septic shock: a randomized clinical trial / Morelli, Andrea; Ertmer, Christian; Westphal, Martin; Rehberg, Sebastian; Kampmeier, Tim; Ligges, Sandra; Orecchioni, Alessandra; D'Egidio, Annalia; D'Ippoliti, Fiorella; Raffone, Cristina; Venditti, Mario; Guarracino, Fabio; Girardis, Massimo; Tritapepe, Luigi; Pietropaoli, Paolo; Mebazaa, Alexander; Singer, Mervyn. - In: JAMA. - ISSN 0098-7484. - STAMPA. - 310:(2013), pp. 1683-1691. [10.1001/jama.2013.278477]
Effect of heart rate control with esmolol on hemodynamic and clinical outcomes in patients with septic shock: a randomized clinical trial
GIRARDIS, Massimo;
2013
Abstract
β-Blocker therapy may control heart rate and attenuate the deleterious effects of β-adrenergic receptor stimulation in septic shock. However, β-Blockers are not traditionally used for this condition and may worsen cardiovascular decompensation related through negative inotropic and hypotensive effects.
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