This paper reports a RP-HPLC method for the determination in topics of azelaic acid, a keratolytic and anti-comedogenic agent widely used in the treatment of all types of acne. A derivatization step was needed prior to chromatographic analysis because the analyte is lacking in chromophore. A sample clean-up procedure by solid-phase extraction was also developed to analyse azelaic acid in complex matrices, such as pharmaceutical and cosmetic formulations.

DETERMINATION OF AZELAIC ACID IN PHARMACEUTICALS AND COSMETICS BY RP-HPLC AFTER PRECOLUMN DERIVATIZATION / Ferioli, Valeria; Rustichelli, Cecilia; Vezzalini, Francesca; Gamberini, Gianfranco. - In: IL FARMACO. - ISSN 0014-827X. - STAMPA. - 49:(1994), pp. 421-425.

DETERMINATION OF AZELAIC ACID IN PHARMACEUTICALS AND COSMETICS BY RP-HPLC AFTER PRECOLUMN DERIVATIZATION

FERIOLI, Valeria;RUSTICHELLI, Cecilia;VEZZALINI, Francesca;GAMBERINI, Gianfranco
1994

Abstract

This paper reports a RP-HPLC method for the determination in topics of azelaic acid, a keratolytic and anti-comedogenic agent widely used in the treatment of all types of acne. A derivatization step was needed prior to chromatographic analysis because the analyte is lacking in chromophore. A sample clean-up procedure by solid-phase extraction was also developed to analyse azelaic acid in complex matrices, such as pharmaceutical and cosmetic formulations.
49
421
425
DETERMINATION OF AZELAIC ACID IN PHARMACEUTICALS AND COSMETICS BY RP-HPLC AFTER PRECOLUMN DERIVATIZATION / Ferioli, Valeria; Rustichelli, Cecilia; Vezzalini, Francesca; Gamberini, Gianfranco. - In: IL FARMACO. - ISSN 0014-827X. - STAMPA. - 49:(1994), pp. 421-425.
Ferioli, Valeria; Rustichelli, Cecilia; Vezzalini, Francesca; Gamberini, Gianfranco
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/10579
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