Androgen deficiency occurs frequently in men with human immunodeficiency virus (HIV) infection. Antiretroviral treatments had reduced the prevalence of male hypogonadism. The pathogenesis of testosterone (T) deficiency in HIV is multifactorial. Several mechanisms have been proposed; among them, drugs, fat redistribution, and a poor health status could explain the mechanism leading to gonadotropins inhibition and hypogonadotropic hypogonadism. The diagnosis of hypogonadism in HIV-infected men should be made based on clinical symptoms and a specific workup including T measurement. The interpretation of the results of biochemical testing is more difficult in men with HIV due to several confounding factors. T treatment should be offered to HIV-infected men with documented clinical hypogonadism and symptoms, especially if they are losing lean mass.

Hypogonadism in the HIV-infected man / Rochira, Vincenzo; Guaraldi, Giovanni. - In: ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA. - ISSN 0889-8529. - STAMPA. - 43:(2014), pp. 709-730. [10.1016/j.ecl.2014.06.005]

Hypogonadism in the HIV-infected man

ROCHIRA, Vincenzo;GUARALDI, Giovanni
2014

Abstract

Androgen deficiency occurs frequently in men with human immunodeficiency virus (HIV) infection. Antiretroviral treatments had reduced the prevalence of male hypogonadism. The pathogenesis of testosterone (T) deficiency in HIV is multifactorial. Several mechanisms have been proposed; among them, drugs, fat redistribution, and a poor health status could explain the mechanism leading to gonadotropins inhibition and hypogonadotropic hypogonadism. The diagnosis of hypogonadism in HIV-infected men should be made based on clinical symptoms and a specific workup including T measurement. The interpretation of the results of biochemical testing is more difficult in men with HIV due to several confounding factors. T treatment should be offered to HIV-infected men with documented clinical hypogonadism and symptoms, especially if they are losing lean mass.
2014
43
709
730
Hypogonadism in the HIV-infected man / Rochira, Vincenzo; Guaraldi, Giovanni. - In: ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA. - ISSN 0889-8529. - STAMPA. - 43:(2014), pp. 709-730. [10.1016/j.ecl.2014.06.005]
Rochira, Vincenzo; Guaraldi, Giovanni
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1040317
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