Multivalency is widely used in nature in specific recognition processes. This paper describes an approach to multivalency in the pentameric 5-HT 3 receptor, a ligand-gated ion channel, which constitutes an example of intrinsically multivalent biological receptors. Owing to the picomolar K i value, TETRA-L represents an outstanding multivalent ligand for the neurotransmitter receptor.
Dendrimeric tetravalent ligands for the serotonin-gated ion channel / Marco, Paolino; Laura, Mennuni; Germano, Giuliani; Maurizio, Anzini; Marco, Lanza; Gianfranco, Caselli; Chiara, Galimberti; Menziani, Maria Cristina; Alessandro, Donati; Andrea, Cappelli. - In: CHEMICAL COMMUNICATIONS. - ISSN 1364-548X. - STAMPA. - 50:(2014), pp. 8582-8585. [10.1039/c4cc02502d]
Dendrimeric tetravalent ligands for the serotonin-gated ion channel
MENZIANI, Maria Cristina;
2014
Abstract
Multivalency is widely used in nature in specific recognition processes. This paper describes an approach to multivalency in the pentameric 5-HT 3 receptor, a ligand-gated ion channel, which constitutes an example of intrinsically multivalent biological receptors. Owing to the picomolar K i value, TETRA-L represents an outstanding multivalent ligand for the neurotransmitter receptor.
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