The encapsulation of a small peptide in SLN was achieved modifying the hot high shear homogenization method. The data obtained by the comparison of SLN to standard Liposomes suggested that even if Liposomes are more efficient carrier for hydrophilic peptides, it is possible to embed this kind of molecules in a solid lipid matrix achieving carriers with higher in vitro stability and lower cytotoxicity. Moreover, the ability of the loaded carriers to reduce the cell viability more efficiently than the unloaded vectors, indicates that the peptide was released inside the cell environment being able to exert its action.

Development of lipid nanocarriers as delivery systems for a small peptide with anti-ovarian activity / Sacchetti, Francesca; Cazzato, ADDOLORATA STEFANIA; Marraccini, Chiara; Cannazza, Giuseppe; Iannuccelli, Valentina; Maretti, Eleonora; Costi, Maria Paola; Leo, Eliana Grazia. - STAMPA. - 1:(2014), pp. ND-ND. ((Intervento presentato al convegno 9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology tenutosi a Lisbon nel 31 March - 3 April 2014.

Development of lipid nanocarriers as delivery systems for a small peptide with anti-ovarian activity

SACCHETTI, FRANCESCA;CAZZATO, ADDOLORATA STEFANIA;MARRACCINI, CHIARA;CANNAZZA, Giuseppe;IANNUCCELLI, Valentina;MARETTI, ELEONORA;COSTI, Maria Paola;LEO, Eliana Grazia
2014

Abstract

The encapsulation of a small peptide in SLN was achieved modifying the hot high shear homogenization method. The data obtained by the comparison of SLN to standard Liposomes suggested that even if Liposomes are more efficient carrier for hydrophilic peptides, it is possible to embed this kind of molecules in a solid lipid matrix achieving carriers with higher in vitro stability and lower cytotoxicity. Moreover, the ability of the loaded carriers to reduce the cell viability more efficiently than the unloaded vectors, indicates that the peptide was released inside the cell environment being able to exert its action.
9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology
Lisbon
31 March - 3 April 2014
Sacchetti, Francesca; Cazzato, ADDOLORATA STEFANIA; Marraccini, Chiara; Cannazza, Giuseppe; Iannuccelli, Valentina; Maretti, Eleonora; Costi, Maria Paola; Leo, Eliana Grazia
Development of lipid nanocarriers as delivery systems for a small peptide with anti-ovarian activity / Sacchetti, Francesca; Cazzato, ADDOLORATA STEFANIA; Marraccini, Chiara; Cannazza, Giuseppe; Iannuccelli, Valentina; Maretti, Eleonora; Costi, Maria Paola; Leo, Eliana Grazia. - STAMPA. - 1:(2014), pp. ND-ND. ((Intervento presentato al convegno 9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology tenutosi a Lisbon nel 31 March - 3 April 2014.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/1029915
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