Here, for the first time, an ancestral bacterial heme peroxidase has been cloned and purified. It is shown to catalyse (besides conventional peroxidase activity) bromide and chloride oxidation more efficiently than LPO and MPO. The structure-function relationships of this new peroxidase in relation to its mammalian counterparts and its putative physiological role are discussed.

New highly stable chlorinating bacterial peroxidase with autocatalytically formed covalent heme to protein bonds / P. G., Furtmuller; M., Auer; C., Gruber; K., Pirker; D., Krioss; S., Hofbauer; M., Soudi; C., Obinger; M., Zamocky; Bellei, Marzia; Battistuzzi, Gianantonio. - In: JBIC. - ISSN 0949-8257. - STAMPA. - 19:(2014), pp. S281-S281. (Intervento presentato al convegno 16th International Conference on Biological Inorganic Chemistry (ICBIC) tenutosi a Grenoble, FRANCE nel JULY 22-26, 2013).

New highly stable chlorinating bacterial peroxidase with autocatalytically formed covalent heme to protein bonds

BELLEI, Marzia;BATTISTUZZI, Gianantonio
2014

Abstract

Here, for the first time, an ancestral bacterial heme peroxidase has been cloned and purified. It is shown to catalyse (besides conventional peroxidase activity) bromide and chloride oxidation more efficiently than LPO and MPO. The structure-function relationships of this new peroxidase in relation to its mammalian counterparts and its putative physiological role are discussed.
2014
19
S281
S281
P. G., Furtmuller; M., Auer; C., Gruber; K., Pirker; D., Krioss; S., Hofbauer; M., Soudi; C., Obinger; M., Zamocky; Bellei, Marzia; Battistuzzi, Giana...espandi
New highly stable chlorinating bacterial peroxidase with autocatalytically formed covalent heme to protein bonds / P. G., Furtmuller; M., Auer; C., Gruber; K., Pirker; D., Krioss; S., Hofbauer; M., Soudi; C., Obinger; M., Zamocky; Bellei, Marzia; Battistuzzi, Gianantonio. - In: JBIC. - ISSN 0949-8257. - STAMPA. - 19:(2014), pp. S281-S281. (Intervento presentato al convegno 16th International Conference on Biological Inorganic Chemistry (ICBIC) tenutosi a Grenoble, FRANCE nel JULY 22-26, 2013).
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1026519
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