This report demonstrates the presence of the immunoreactive enzyme nitric oxide (NO) synthase in the molluscan hemocytes of Viviparus ater. Bacterial elimination by the hemocytes occurs through phagocytosis and the nitric oxide (NO) system, These processes are correlated, and the hemocytes activate phagocytosis before the NO defence response. This behaviour could be explained by the fact that, as in vertebrate macrophages, NO synthase can also be induced in invertebrate hemocytes, Indeed, in the bacteria-activated hemocytes there is an increase of NO synthase in comparison to controls, Moreover, the same behaviour is also seen in the NADPH diaphorase activity, These findings suggest a pivotal role of the NO system in defence mechanisms, and indicate that, as with phagocytosis, this system developed very early in the course of evolution.

INVERTEBRATE IMMUNOCYTES - RELATIONSHIP BETWEEN PHAGOCYTOSIS AND NITRIC-OXIDE PRODUCTION / Franchini, Antonella; Fontanili, P; Ottaviani, Enzo. - In: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY. PART B, BIOCHEMISTRY & MOLECULAR BIOLOGY. - ISSN 1096-4959. - STAMPA. - 110:(1995), pp. 403-407.

INVERTEBRATE IMMUNOCYTES - RELATIONSHIP BETWEEN PHAGOCYTOSIS AND NITRIC-OXIDE PRODUCTION

FRANCHINI, Antonella;OTTAVIANI, Enzo
1995

Abstract

This report demonstrates the presence of the immunoreactive enzyme nitric oxide (NO) synthase in the molluscan hemocytes of Viviparus ater. Bacterial elimination by the hemocytes occurs through phagocytosis and the nitric oxide (NO) system, These processes are correlated, and the hemocytes activate phagocytosis before the NO defence response. This behaviour could be explained by the fact that, as in vertebrate macrophages, NO synthase can also be induced in invertebrate hemocytes, Indeed, in the bacteria-activated hemocytes there is an increase of NO synthase in comparison to controls, Moreover, the same behaviour is also seen in the NADPH diaphorase activity, These findings suggest a pivotal role of the NO system in defence mechanisms, and indicate that, as with phagocytosis, this system developed very early in the course of evolution.
1995
110
403
407
INVERTEBRATE IMMUNOCYTES - RELATIONSHIP BETWEEN PHAGOCYTOSIS AND NITRIC-OXIDE PRODUCTION / Franchini, Antonella; Fontanili, P; Ottaviani, Enzo. - In: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY. PART B, BIOCHEMISTRY & MOLECULAR BIOLOGY. - ISSN 1096-4959. - STAMPA. - 110:(1995), pp. 403-407.
Franchini, Antonella; Fontanili, P; Ottaviani, Enzo
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/10260
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