In the present study we have demonstrated that lipopolysaccharide (LPS) acts as an activator in the immunocytes of molluscs Planorbarius corneus, Mytilus edulis, and the insect Leucophaea maderae. This stimulatory effect, demonstrated by cellular conformational changes, is concentration- and time-dependent, and is antagonized by morphine. The inhibitory effect of morphine carl be counteracted by naloxone. Morphine inhibitory action on immunocyte activity is also demonstrated by a decrease in the phagacytic activity. These data suggest that the downregulation of morphine is not limited to vertebrates but is also present in invertebrates.
ANTAGONIZING EFFECT OF MORPHINE ON THE MOBILITY AND PHAGOCYTIC-ACTIVITY OF INVERTEBRATE IMMUNOCYTES / Ottaviani, Enzo; Franchini, Antonella; Sonetti, Dario; Stefano, Gb. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - STAMPA. - 276:(1995), pp. 35-39.
ANTAGONIZING EFFECT OF MORPHINE ON THE MOBILITY AND PHAGOCYTIC-ACTIVITY OF INVERTEBRATE IMMUNOCYTES
OTTAVIANI, Enzo;FRANCHINI, Antonella;SONETTI, Dario;
1995
Abstract
In the present study we have demonstrated that lipopolysaccharide (LPS) acts as an activator in the immunocytes of molluscs Planorbarius corneus, Mytilus edulis, and the insect Leucophaea maderae. This stimulatory effect, demonstrated by cellular conformational changes, is concentration- and time-dependent, and is antagonized by morphine. The inhibitory effect of morphine carl be counteracted by naloxone. Morphine inhibitory action on immunocyte activity is also demonstrated by a decrease in the phagacytic activity. These data suggest that the downregulation of morphine is not limited to vertebrates but is also present in invertebrates.
Pubblicazioni consigliate
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris
