Maternal diabetes preceding pregnancy may increase the risk of birth defects in the offspring, but not all studies confirm this association, which has shown considerable variation over time, and the effect of having type 1 versus type 2 diabetes is unclear. We conducted a population-based cohort study in the Northern Italy Emilia-Romagna region linking administrative databases with a Birth Defects Registry. From hospital discharge records we identified all diabetic pregnancies during 1997-2010, and a population of non-diabetic parturients matched for age, residence, year and delivery hospital. We collected available information on education, smoking and drug prescriptions, from which we inferred the type of diabetes. We found 62 malformed infants out of 2,269 births among diabetic women, and 162 out of 10,648 births among non-diabetic women. The age-standardized prevalence ratio (PR) of malformation associated with maternal pregestational diabetes was 1.79 (95 % confidence interval 1.34-2.39), a value that varied little by age. Type of diabetes strongly influenced the PR, with higher values related to type 2 diabetic women. Most major subgroups of anomalies had PRs above 1, including cardiovascular, genitourinary, musculoskeletal, and chromosomal abnormalities. There was an unusually high PR for the rare defect 'extra-ribs', but it was based on only two cases. This study indicates that maternal pregestational type 2 diabetes is associated with a higher prevalence of specific birth defects in offspring, whereas for type 1 diabetic mothers, particularly in recent years, the association was unremarkable.

Risk of birth defects associated with maternal pregestational diabetes / Vinceti, Marco; Malagoli, Carlotta; Rothman, Kj; Rodolfi, R; Astolfi, G; Calzolari, E; Puccini, A; Bertolotti, Marco; Lunt, M; Paterlini, L; Martini, M; Nicolini, F.. - In: EUROPEAN JOURNAL OF EPIDEMIOLOGY. - ISSN 0393-2990. - STAMPA. - 29:(2014), pp. 411-418. [10.1007/s10654-014-9913-4]

Risk of birth defects associated with maternal pregestational diabetes.

VINCETI, Marco;MALAGOLI, Carlotta;BERTOLOTTI, Marco;
2014

Abstract

Maternal diabetes preceding pregnancy may increase the risk of birth defects in the offspring, but not all studies confirm this association, which has shown considerable variation over time, and the effect of having type 1 versus type 2 diabetes is unclear. We conducted a population-based cohort study in the Northern Italy Emilia-Romagna region linking administrative databases with a Birth Defects Registry. From hospital discharge records we identified all diabetic pregnancies during 1997-2010, and a population of non-diabetic parturients matched for age, residence, year and delivery hospital. We collected available information on education, smoking and drug prescriptions, from which we inferred the type of diabetes. We found 62 malformed infants out of 2,269 births among diabetic women, and 162 out of 10,648 births among non-diabetic women. The age-standardized prevalence ratio (PR) of malformation associated with maternal pregestational diabetes was 1.79 (95 % confidence interval 1.34-2.39), a value that varied little by age. Type of diabetes strongly influenced the PR, with higher values related to type 2 diabetic women. Most major subgroups of anomalies had PRs above 1, including cardiovascular, genitourinary, musculoskeletal, and chromosomal abnormalities. There was an unusually high PR for the rare defect 'extra-ribs', but it was based on only two cases. This study indicates that maternal pregestational type 2 diabetes is associated with a higher prevalence of specific birth defects in offspring, whereas for type 1 diabetic mothers, particularly in recent years, the association was unremarkable.
2014
29
411
418
Risk of birth defects associated with maternal pregestational diabetes / Vinceti, Marco; Malagoli, Carlotta; Rothman, Kj; Rodolfi, R; Astolfi, G; Calzolari, E; Puccini, A; Bertolotti, Marco; Lunt, M; Paterlini, L; Martini, M; Nicolini, F.. - In: EUROPEAN JOURNAL OF EPIDEMIOLOGY. - ISSN 0393-2990. - STAMPA. - 29:(2014), pp. 411-418. [10.1007/s10654-014-9913-4]
Vinceti, Marco; Malagoli, Carlotta; Rothman, Kj; Rodolfi, R; Astolfi, G; Calzolari, E; Puccini, A; Bertolotti, Marco; Lunt, M; Paterlini, L; Martini, M; Nicolini, F.
File in questo prodotto:
File Dimensione Formato  
art%3A10.1007%2Fs10654-014-9913-4.pdf

Accesso riservato

Tipologia: Versione pubblicata dall'editore
Dimensione 204.84 kB
Formato Adobe PDF
204.84 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1018914
Citazioni
  • ???jsp.display-item.citation.pmc??? 14
  • Scopus 42
  • ???jsp.display-item.citation.isi??? 42
social impact