By in vitro studies, it was found that beta-endorphin (beta-EP) stimulates estradiol-17 beta and progesterone secretion in the ovary of reproductive lizard Podarcis s. sicula; these effects were reversed by naloxone. In the post-ovulatory follicles no significant changes were observed in the progesterone titres, when the medium was supplemented by beta-EP and/or naloxone; conversely, estradiol-17 beta was stimulated by beta-EP and this effect was abolished by naloxone. The data reported here provide evidence for the tonic activity of an endogenous opioid system in the ovary of this lizard. The action exerted by homologous pituitary, moreover, has also been evaluated in order to compare the effects of beta-EP with these of pituitary gland, generally considered the physiological trigger of gonadal function.
THE PRO-OPIOMELANOCORTIN-DERIVED PEPTIDE, BETA-ENDORPHIN, REGULATES OVARIAN-FUNCTION IN THE REPRODUCTIVE LIZARD, PODARCIS S. SICULA RAF / Polzonettimagni, Am; Carnevali, O; Mosconi, G; Nabissi, M; Facchinetti, Fabio. - In: ENDOCRINE. - ISSN 1355-008X. - STAMPA. - 2:(1994), pp. 665-668.
THE PRO-OPIOMELANOCORTIN-DERIVED PEPTIDE, BETA-ENDORPHIN, REGULATES OVARIAN-FUNCTION IN THE REPRODUCTIVE LIZARD, PODARCIS S. SICULA RAF
FACCHINETTI, Fabio
1994
Abstract
By in vitro studies, it was found that beta-endorphin (beta-EP) stimulates estradiol-17 beta and progesterone secretion in the ovary of reproductive lizard Podarcis s. sicula; these effects were reversed by naloxone. In the post-ovulatory follicles no significant changes were observed in the progesterone titres, when the medium was supplemented by beta-EP and/or naloxone; conversely, estradiol-17 beta was stimulated by beta-EP and this effect was abolished by naloxone. The data reported here provide evidence for the tonic activity of an endogenous opioid system in the ovary of this lizard. The action exerted by homologous pituitary, moreover, has also been evaluated in order to compare the effects of beta-EP with these of pituitary gland, generally considered the physiological trigger of gonadal function.
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