A 39-year-old woman was diagnosed with acute promyelocytic leukemia (APL) with disseminated intravascular coagulation syndrome. The hematologic examination showed a morphologic, cytochemical, and immunophenotypic picture typical of an APL, with a marked leukocytosis and a mixed population of hypergranular and microgranular promyelocytes. The cytogenetic analysis showed a 46,XX,t(9;22) karyotype, without any alterations of chromosomes 15 and 17. The t(15;17) translocation was not evident in FISH experiments, while a molecular analysis revealed the presence of a PML-RAR alpha chimera.
DETECTION OF PML-RAR-ALPHA FUSION TRANSCRIPT IN PH POSITIVE LEUKEMIA WITH ACUTE PROMYELOCYTIC PHENOTYPE LACKING THE T(15-17) CYTOGENETIC ABNORMALITY / Emilia, G; Marasca, Roberto; Longo, G; Ferrari, Mg; Notohamiprodjo, M; Temperani, Paola; Sacchi, Stefano; Torelli, Giuseppe. - In: CANCER GENETICS AND CYTOGENETICS. - ISSN 0165-4608. - STAMPA. - 80:(1995), pp. 95-99.
DETECTION OF PML-RAR-ALPHA FUSION TRANSCRIPT IN PH POSITIVE LEUKEMIA WITH ACUTE PROMYELOCYTIC PHENOTYPE LACKING THE T(15-17) CYTOGENETIC ABNORMALITY
MARASCA, Roberto;TEMPERANI, Paola;SACCHI, Stefano;TORELLI, Giuseppe
1995
Abstract
A 39-year-old woman was diagnosed with acute promyelocytic leukemia (APL) with disseminated intravascular coagulation syndrome. The hematologic examination showed a morphologic, cytochemical, and immunophenotypic picture typical of an APL, with a marked leukocytosis and a mixed population of hypergranular and microgranular promyelocytes. The cytogenetic analysis showed a 46,XX,t(9;22) karyotype, without any alterations of chromosomes 15 and 17. The t(15;17) translocation was not evident in FISH experiments, while a molecular analysis revealed the presence of a PML-RAR alpha chimera.
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