The presence of immunoreactive pro-opiomelanocortin (POMC)-derived peptides (adrenocorticotropin hormone, beta-endorphin, alpha-melanocyte-stimulating hormone) and of cytokine-like molecules [interleukin (IL)-1 alpha, IL-1 beta, IL-2, IL-6, tumour necrosis factor-alpha] was demonstrated in periodic acid-Schiff-positive epithelial cells in the thymus of the goldfish (Carassius c. auratus) using immunocytochemical procedures. POMC-derived peptide- and cytokine-like molecules were localized in the same cell type. Lymphocytes were negative for all the above mentioned molecules. Despite the smaller number of cells positive for neuropeptide- and cytokine-like molecules, our findings suggest that immune-neuroendocrine interactions are likely to occur in the thymus of goldfish.

EVIDENCE FOR THE PRESENCE OF IMMUNOREACTIVE POMC-DERIVED PEPTIDES AND CYTOKINES IN THE THYMUS OF THE GOLDFISH (CARASSIUS-C-AURATUS) / Ottaviani, Enzo; Franchini, Antonella; Franceschi, C.. - In: HISTOCHEMICAL JOURNAL. - ISSN 0018-2214. - STAMPA. - 27:(1995), pp. 597-601. [10.1007/BF02388458]

EVIDENCE FOR THE PRESENCE OF IMMUNOREACTIVE POMC-DERIVED PEPTIDES AND CYTOKINES IN THE THYMUS OF THE GOLDFISH (CARASSIUS-C-AURATUS)

OTTAVIANI, Enzo;FRANCHINI, Antonella;
1995

Abstract

The presence of immunoreactive pro-opiomelanocortin (POMC)-derived peptides (adrenocorticotropin hormone, beta-endorphin, alpha-melanocyte-stimulating hormone) and of cytokine-like molecules [interleukin (IL)-1 alpha, IL-1 beta, IL-2, IL-6, tumour necrosis factor-alpha] was demonstrated in periodic acid-Schiff-positive epithelial cells in the thymus of the goldfish (Carassius c. auratus) using immunocytochemical procedures. POMC-derived peptide- and cytokine-like molecules were localized in the same cell type. Lymphocytes were negative for all the above mentioned molecules. Despite the smaller number of cells positive for neuropeptide- and cytokine-like molecules, our findings suggest that immune-neuroendocrine interactions are likely to occur in the thymus of goldfish.
27
597
601
EVIDENCE FOR THE PRESENCE OF IMMUNOREACTIVE POMC-DERIVED PEPTIDES AND CYTOKINES IN THE THYMUS OF THE GOLDFISH (CARASSIUS-C-AURATUS) / Ottaviani, Enzo; Franchini, Antonella; Franceschi, C.. - In: HISTOCHEMICAL JOURNAL. - ISSN 0018-2214. - STAMPA. - 27:(1995), pp. 597-601. [10.1007/BF02388458]
Ottaviani, Enzo; Franchini, Antonella; Franceschi, C.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/10027
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