HIGH PREVALENCE OF VITAMIN D DEFICIENCY IN A COHORT OF HIV INFECTED PREGNANT AND NON-PREGNANT WOMEN OF CHILDBEARING AGE

Aims: To analyze prevalence and risk factors for 25(OH) VitaminD [25(OH)D] plasma levels < 20ng/mL among HIV-infected pregnant and non-pregnant women. Methods: Cross-sectional, case-control study comparing HIV-infected pregnant women at third trimester enrolled between 2003 and 2010 in the Italian National Program on Surveillance on Antiretroviral Treatment in Pregnancy and HIV-infected non-pregnant women followed within the Modena Metabolic Clinic. The two groups were matched for age, seasonality of 25(OH)D measurement and body mass index. Quantitative determinations of 25(OH)D were measured using chemiluminescent immunoassay (CLIA) technology. Results: Two hundred twelve HIV-infected women were studied. African ethnicity was more common in the group of pregnant women (37.6% vs.10.5%). Two groups had similar prevalence of 25(OH)D levels < 20ng/mL (64.1% vs. 54.7%, respectively; p=0.166). At univariate logistic regression analysis, only black ethnicity was found to be different in two study groups (0.015). Multivariate analysis is shown in table1. Conclusion: This study shows a high prevalence of vitaminD deficiency in both groups. Pregnancy per se didn't result an independent risk factor for vitamin D deficiency. Both groups recognized traditional risk factors for vitaminD deficiency