Introduction: We performed a population-based study to assess amyotrophic lateral sclerosis (ALS) survival after noninvasive ventilation (NIV), invasive ventilation (IV), and enteral nutrition (EN). Methods: We included patients diagnosed from 2000 to 2009 in Modena, where a prospective registry and a Motor Neuron Diseases Centre have been active since 2000. Results: Of the 193 incident cases, 47.7% received NIV, 24.3% received tracheostomy, and 49.2% received EN. A total of 10.4% of the patients refused NIV, 31.6% refused IV, and 8.7% refused EN. The median survival times after NIV, IV, and EN were 15, 19, and 9 months, respectively. Of the tracheostomized patients, 79.7% were discharged from the hospital; 73.0% were discharged to home. The median survival times for tracheostomized patients who were cared for at home and in nursing homes were 43 and 2 months, respectively. The multivariate analysis demonstrated that the place of discharge was the only independent prognostic factor after IV (P<0.01). Conclusions: Service organizations may promote adherence to NIV, IV, EN, and influence postprocedure survival. These data may be useful in defining health plans regarding advanced ALS care and in patient counseling.
|Data di pubblicazione:||2014|
|Titolo:||Non-invasive and invasive ventilation and enteral nutrition for ALS in Italy.|
|Autore/i:||Fini, N; Georgoulopoulou, E; Vinceti, Marco; Monelli, M; Pinelli, G; Vacondio, P; Giovannini, M; Dallari, R; Marudi, A; Mandrioli, Jessica|
|Digital Object Identifier (DOI):||10.1002/mus.24187|
|Codice identificativo ISI:||WOS:000342634100006|
|Codice identificativo Scopus:||2-s2.0-84922480491|
|Codice identificativo Pubmed:||24448736|
|Citazione:||Non-invasive and invasive ventilation and enteral nutrition for ALS in Italy / Fini, N; Georgoulopoulou, E; Vinceti, Marco; Monelli, M; Pinelli, G; Vacondio, P; Giovannini, M; Dallari, R; Marudi, A; Mandrioli, Jessica. - In: MUSCLE & NERVE. - ISSN 0148-639X. - STAMPA. - 50(2014), pp. 508-516.|
|Tipologia||Articolo su rivista|
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