| Nome |
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Folic Acid-Peptide Conjugates Combine Selective Cancer Cell Internalization with Thymidylate Synthase Dimer Interface Targeting, file e31e124f-6460-987f-e053-3705fe0a095a
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402
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Repurposing of drugs targeting yap-tead functions, file e31e124d-9360-987f-e053-3705fe0a095a
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296
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Protein–protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase, file e31e124b-6883-987f-e053-3705fe0a095a
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278
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Targeting Oxidatively Induced DNA Damage Response in Cancer: Opportunities for Novel Cancer Therapies, file e31e124d-4603-987f-e053-3705fe0a095a
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241
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Modulation of the expression of folate cycle enzymes and polyamine metabolism by berberine in cisplatin-sensitive and -resistant human ovarian cancer cells, file e31e124b-3ceb-987f-e053-3705fe0a095a
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213
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Concurrent inhibition of enzymatic activity and NF-Y-mediated transcription of Topoisomerase-IIα by bis-DemethoxyCurcumin in cancer cells, file e31e124b-2524-987f-e053-3705fe0a095a
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198
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Intracellular quantitative detection of human thymidylate synthase engagement with an unconventional inhibitor using tetracysteine-diarsenical-probe technology, file e31e124b-a0f6-987f-e053-3705fe0a095a
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183
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Heat shock protein 90 and serine/threonine kinase B-Raf inhibitors have overlapping chemical space, file e31e124c-e036-987f-e053-3705fe0a095a
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167
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The 1,10-phenanthroline ligand enhances the antiproliferative activity of dna-intercalating thiourea-pd(Ii) and-pt(ii) complexes against cisplatin-sensitive and-resistant human ovarian cancer cell lines, file e31e124d-da2d-987f-e053-3705fe0a095a
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156
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Translational repression of thymidylate synthase by targeting its mRNA, file e31e124b-1dcd-987f-e053-3705fe0a095a
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155
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Proteomic and bioinformatic studies for the characterization of response to pemetrexed in platinum drug resistant ovarian cancer, file e31e124d-83f4-987f-e053-3705fe0a095a
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150
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Depletion of Trichoplein (TpMs) Causes Chromosome Mis-Segregation, DNA Damage and Chromosome Instability in Cancer Cells, file e31e124e-8b64-987f-e053-3705fe0a095a
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143
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A Peptidic Thymidylate-Synthase Inhibitor Loaded on Pegylated Liposomes Enhances the Antitumour Effect of Chemotherapy Drugs in Human Ovarian Cancer Cells, file e31e124e-3af2-987f-e053-3705fe0a095a
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139
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Transcriptional activation and cell cycle block are the keys for 5-fluorouracil induced up-regulation of human thymidylate synthase expression, file e31e124b-1c2d-987f-e053-3705fe0a095a
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135
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Cyclic Peptides Acting as Allosteric Inhibitors of Human Thymidylate Synthase and Cancer Cell Growth, file e31e124d-ca31-987f-e053-3705fe0a095a
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126
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Serum Mass Spectrometry Proteomics and Protein Set Identification in Response to FOLFOX-4 in Drug-Resistant Ovarian Carcinoma, file 115add2d-5a73-42f8-b973-dd6d459b310d
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120
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Structural bases for the synergistic inhibition of human thymidylate synthase and ovarian cancer cell growth by drug combinations, file e31e124f-9c9d-987f-e053-3705fe0a095a
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76
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Designing selective Cys-ligands to unpair the binding of the Human Transcription Enhancer Associated Domain 4 (hTEAD-4) with its modulators to halt cancer cell growth, file e31e124f-91d0-987f-e053-3705fe0a095a
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43
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Virtual Screening and X-ray Crystallography Identify Non-Substrate Analog Inhibitors of Flavin-Dependent Thymidylate Synthase, file e31e1250-aac5-987f-e053-3705fe0a095a
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40
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Peptides binding to the dimer interface of thymidylate synthase for the treatment of cancer-US8916679 “B2 - Granted patent as second publication”., file e31e124a-c526-987f-e053-3705fe0a095a
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38
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Telomere Dysfunction Is Associated with Altered {DNA} Organization in Trichoplein/Tchp/Mitostatin ({TpMs}) Depleted Cells, file 45facfef-f67f-44e2-a375-fc100ab51892
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26
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pH-Promoted Release of a Novel Anti-Tumour Peptide by “Stealth” Liposomes: Effect of Nanocarriers on the Drug Activity in Cis-Platinum Resistant Cancer Cells, file e31e1250-700f-987f-e053-3705fe0a095a
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25
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A toolbox of biophysical and analytical assays helps to confirm the activity of novel hTS dimer disrupters (Ddis) with anticancer properties, file a6638a6a-bdcc-4203-8baf-385dd3872252
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24
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Development of a novel class of YAP:TEAD interface-3 molecular disruptors to treat colorectal carcinoma, file 2ddbc408-4788-4c10-b0d4-ea4913085e81
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23
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The 1,10-phenanthroline ligand enhances the antiproliferative activity of dna-intercalating thiourea-pd(Ii) and-pt(ii) complexes against cisplatin-sensitive and-resistant human ovarian cancer cell lines, file e31e124d-e59b-987f-e053-3705fe0a095a
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23
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Integrating MS proteomics in the Medicinal Chemistry pipeline as powerful tool to overcome drug resistance issues in colorectal cancer, file eec0b667-180d-4630-ad4b-35a4a08cd9f3
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23
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Cellular uptake and metabolic degradation of a conjugate of folic acid with an anticancer peptide targeting the human Thymidylate synthase enzyme, file e31e1250-0e2a-987f-e053-3705fe0a095a
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19
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A Peptidic Thymidylate-Synthase Inhibitor Loaded on Pegylated Liposomes Enhances the Antitumour Effect of Chemotherapy Drugs in Human Ovarian Cancer Cells, file e31e124e-4716-987f-e053-3705fe0a095a
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18
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Targeting the Interplay of Independent Cellular Pathways and Immunity: A Challenge in Cancer Immunotherapy, file d1de4bd3-4c52-4594-9b3a-35dfddad01ea
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17
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Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth, file a2cae1de-bd1b-426b-91e9-1b996303dd0b
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16
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LC-MS serum proteomics reveals a panel of proteins prognostic of positive responsiveness to bevacizumab therapy in late-stages ovarian cancer patients, file f692143a-b58e-4062-a1a3-947796ac06ce
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16
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Lead optimization of human thymidylate synthase dimer disrupters: from computational studies to evaluation of their biological profiles, file 13f336c6-8fa5-4469-9fbf-02448430cda9
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15
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Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth, file aa21c5db-c206-459d-83d7-a5a0a3c06e02
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13
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Identification of a Quinone Derivative as a YAP/TEAD Activity Modulator from a Repurposing Library, file cd6e45e3-17cf-4847-a275-f01c5213e6e5
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12
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Lead-optimization process and characterization of the dissociative effect applied to new dimer disrupters of human Thymidylate Synthase, file 0ca67a23-2652-4924-b376-42980df36080
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9
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Precision medicine through proteomics studies in drug resistant colorectal cancer, file 8c5009ef-314b-4e85-87b5-891ec2747a91
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8
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Modulation of cis-diamminedichloroplatinum(II) accumulation and cytotoxicity by spermine in sensitive and resistant human ovarian carcinoma cells., file e31e124b-3764-987f-e053-3705fe0a095a
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8
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Dabrafenib-Panobinostat Salt: Improving Dissolution Rate and Inhibition of BRAF Melanoma Cells, file 548028a2-2594-42c7-90b7-e5f391b4789d
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7
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Development of a sensitive biochemical tool to assess the expression levels of recombinant ectopic proteins in in vitro engineered cellular systems, file a70353c0-b6be-4929-93f2-b44e59752349
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7
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Mass Spectrometric/Bioinformatic Identification of a Protein Subset That Characterizes the Cellular Activity of Anticancer Peptides, file e31e124b-3cea-987f-e053-3705fe0a095a
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4
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N-(naphthyl)-N′-(methoxy carbonyl)thiocarbamide and its Cu(I) complex: synthesis, spectroscopic, X-ray, DFT andin vitrocytotoxicity study, file e31e124b-3f4c-987f-e053-3705fe0a095a
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4
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Virtual Screening and X-ray Crystallography Identify Non-Substrate Analog Inhibitors of Flavin-Dependent Thymidylate Synthase, file e31e124b-f3e1-987f-e053-3705fe0a095a
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4
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Structural insight into YAP-TEAD4 protein-protein interactions as target for cancer treatment, file 8922c0fe-8a37-40ff-b4fb-b5a72955e768
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3
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ANTICANCER DRUGS, file e31e124d-a391-987f-e053-3705fe0a095a
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3
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Characterization of the cell growth inhibitory effects of a novel DNA-intercalating bipyridyl-thiourea-Pt(II) complex in cisplatin-sensitive and-resistant human ovarian cancer cells, file e31e124b-30a4-987f-e053-3705fe0a095a
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2
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Newly synthesized curcumin derivatives: crosstalk between chemico-physical properties and biological activity., file e31e124b-4327-987f-e053-3705fe0a095a
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2
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pH-Promoted Release of a Novel Anti-Tumour Peptide by “Stealth” Liposomes: Effect of Nanocarriers on the Drug Activity in Cis-Platinum Resistant Cancer Cells, file e31e124d-76c3-987f-e053-3705fe0a095a
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2
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Synthesis, molecular structure exploration and in vitro cytotoxicity screening of five novel N, N′- disubstituted thiocarbamide derivatives, file e31e124d-83ac-987f-e053-3705fe0a095a
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2
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Structural, Hirshfeld surface and in vitro cytotoxicity evaluation of five new N-aryl-N’-alkoxycarbonyl thiocarbamide derivatives., file e31e124f-b1b9-987f-e053-3705fe0a095a
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2
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1H, 13C, 195Pt NMR study on platinum(II) interaction with sulphur containing Amadori compounds, file e31e124a-96fc-987f-e053-3705fe0a095a
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1
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Polyamine depletion switches the form of 2-deoxy-D-ribose-induced cell death from apoptosis to necrosis in HL-60 cells., file e31e124a-98ad-987f-e053-3705fe0a095a
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1
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Spermidine/spermine N1-acetyltransferase transient over-expression restores sensitivity of resistant human ovarian cancer cells to N1,N12-bis(ethyl)spermine and to cisplatin, file e31e124a-9dfb-987f-e053-3705fe0a095a
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1
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Studies on the anti-proliferative effects of novel DNA-intercalating bipyridyl-thiourea-Pt(II) complexes against cisplatin-sensitive and -resistant human ovarian cancer cells, file e31e124a-9e37-987f-e053-3705fe0a095a
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1
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Synthesis, chemical and biological studies on new Fe3þ-glycosilated b-diketo complexes for the treatment of iron deficiency, file e31e124a-9ee3-987f-e053-3705fe0a095a
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1
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Synthesis, cytotoxic and combined cDDP activity of new stable curcumin derivatives, file e31e124a-9f78-987f-e053-3705fe0a095a
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1
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Spermidine/spermine N1-acetyltranferasemodulation by novel folate cycle inhibitors in cisplatin-sensitive and -resistanthuman ovarian cancer cell lines, file e31e124a-a111-987f-e053-3705fe0a095a
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1
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Cisplatin-resistance modulates the effect of protein synthesis inhibitors on spermidine/spermine N-1-acetyltransferase expression, file e31e124b-3b63-987f-e053-3705fe0a095a
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1
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Distamycin A and derivatives as synergic drugs in cisplatin-sensitive and -resistant ovarian cancer cells., file e31e124b-3c80-987f-e053-3705fe0a095a
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1
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Optimization of Peptides That Target Human Thymidylate Synthase
to Inhibit Ovarian Cancer Cell Growth, file e31e124b-3ce9-987f-e053-3705fe0a095a
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1
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Collateral sensitivity to novel thymidylate synthase inhibitors correlates with folate cycle enzymes impairment in cisplatin-resistant human ovarian cancer cells, file e31e124b-4491-987f-e053-3705fe0a095a
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1
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Internalization and stability of a thymidylate synthase peptide inhibitor in ovarian cancer cells, file e31e124b-a730-987f-e053-3705fe0a095a
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1
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Inside the biochemical pathways of thymidylate synthase perturbed by anticancer drugs: Novel strategies to overcome cancer chemoresistance, file e31e124f-488f-987f-e053-3705fe0a095a
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1
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Synthesis, characterization, Hirshfeld surface, cytotoxicity, DNA
damage and cell cycle arrest studies of N, N-diphenyl-N'-(biphenyl-4-
carbonyl/4-chlorobenzoyl) thiocarbamides, file e31e124f-8902-987f-e053-3705fe0a095a
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1
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Stimulation of cis-diamminedichloroplatinum(II) accumulation by modulation of passive permeability with genistein: an altered responce in accumulation-defective resistant cells., file e31e124f-8bb1-987f-e053-3705fe0a095a
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1
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Synthesis, spectroscopic, crystal structure and in vitro cytotoxicity studies of N-thiophenoyl-N'-substituted phenyl thiocarbamide derivatives, file e31e124f-96b2-987f-e053-3705fe0a095a
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1
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Copper (I) complexes of N-(2/4 methoxy/2-chloro-4-nitro) phenyl-N’ (methoxycarbonyl) thiocarbamides as potential anticancer agents: Synthesis, crystal structure, in vitro cytotoxicity and DNA damage studies., file e31e124f-9d6c-987f-e053-3705fe0a095a
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1
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Monodentate Coordination of N, N′-Disubstituted Thiocarbamide Ligands: Syntheses, Structural Analyses, In Vitro Cytotoxicity and DNA Damage Studies of Cu(I) Complexes, file e31e124f-9fab-987f-e053-3705fe0a095a
|
1
|
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Synthesis, characterisation, Hirshfeld surface and in vitro cytotoxicity evaluation of new N-aryl-N0-Alkoxycarbonyl thiocarbamide derivatives., file e31e124f-d3e5-987f-e053-3705fe0a095a
|
1
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|
Experimental and theoretical exploration of molecular structure and anticancer properties of two N, N′–disubstituted thiocarbamide derivatives, file e31e124f-d5cd-987f-e053-3705fe0a095a
|
1
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Differential induction of spermidine/spermine N1-acetyltransferase activity in cisplatin-sensitive and -resistant ovarian cancer cells in response to N1,N12-bis (ethyl)spermine involves transcriptional and post-transcriptional regulation., file e31e124f-e015-987f-e053-3705fe0a095a
|
1
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N-1,N-12-bis(ethyl)spermine effect on growth of cis-diamminedichloroplatinum(II)-sensitive and -resistant human ovarian-carcinoma cell lines, file e31e124f-e017-987f-e053-3705fe0a095a
|
1
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| Totale |
3.658 |
