In rat dorsal horn, little is known about the properties of synaptic NMDA receptors during the first two postnatal weeks, a period of intense synaptogenesis. Using transverse spinal cord slices from postnatal day 0-15 rats, we show that 20% of glutamatergic synapses tested at low-stimulation intensity in spinal cord laminae I and II were mediated exclusively by NMDA receptors. Essentially all of the remaining glutamatergic EPSCs studied were attributable to the activation of both NMDA and AMPA receptors. Synaptic NMDA receptors at pure and mixed synapses showed similar sensitivity to membrane potential, independent of age, indicating similar Mg2+ sensitivity. Kinetic properties of NMDA EPSCs from pure and mixed synapses were measured at +50 mV.
NMDA receptor mediated synaptic transmission in rat spinal cord lamina I and II during postnatal development / Bardoni, Rita; Magherini, Pier Cosimo; Macdermott, Ab. - In: PFLÜGERS ARCHIV. - ISSN 0031-6768. - STAMPA. - 434:(1997), pp. 41-41. (Intervento presentato al convegno SIF annual meeting tenutosi a Firenze nel 1997).
NMDA receptor mediated synaptic transmission in rat spinal cord lamina I and II during postnatal development
BARDONI, Rita;MAGHERINI, Pier Cosimo;
1997
Abstract
In rat dorsal horn, little is known about the properties of synaptic NMDA receptors during the first two postnatal weeks, a period of intense synaptogenesis. Using transverse spinal cord slices from postnatal day 0-15 rats, we show that 20% of glutamatergic synapses tested at low-stimulation intensity in spinal cord laminae I and II were mediated exclusively by NMDA receptors. Essentially all of the remaining glutamatergic EPSCs studied were attributable to the activation of both NMDA and AMPA receptors. Synaptic NMDA receptors at pure and mixed synapses showed similar sensitivity to membrane potential, independent of age, indicating similar Mg2+ sensitivity. Kinetic properties of NMDA EPSCs from pure and mixed synapses were measured at +50 mV.
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