A novel in oil-nanoprecipitation method using a mixture of cottonseed oil and Tween-80 as non-solvent phase has been developed for the nanoincapsulation of water-soluble drugs in poly (D,L-lactide-coglicolide) (PLGA). In this work the method was applied to three hydrophilic drugs with different structure and molecular weight. The results indicate that the CPA stability in whole blood was increased after nanoincapsulation according to the in vitro profile release pattern. The proposed method appears promising for the nanoincapsulation of hydrophilic durgs in hydrophobic polymers.
Release modulation of hydrophilic drugs from polymeric nanoparticles produced by in-oil nanoprecipitation process / Leo, Eliana Grazia; Vighi, Eleonora; B., Pavan; A., Baldisserotto; Iannuccelli, Valentina; A., Dalpiaz. - STAMPA. - ND:(2012), pp. 104-104. (Intervento presentato al convegno XXII Simposio ADRITELF - Firenze 2012 tenutosi a Firenze - Italia nel 13-16 settembre 2012).
Release modulation of hydrophilic drugs from polymeric nanoparticles produced by in-oil nanoprecipitation process
LEO, Eliana Grazia;VIGHI, Eleonora;IANNUCCELLI, Valentina;
2012
Abstract
A novel in oil-nanoprecipitation method using a mixture of cottonseed oil and Tween-80 as non-solvent phase has been developed for the nanoincapsulation of water-soluble drugs in poly (D,L-lactide-coglicolide) (PLGA). In this work the method was applied to three hydrophilic drugs with different structure and molecular weight. The results indicate that the CPA stability in whole blood was increased after nanoincapsulation according to the in vitro profile release pattern. The proposed method appears promising for the nanoincapsulation of hydrophilic durgs in hydrophobic polymers.
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