We report a study of encapsulation and release from PLGA nanoparticles of a prodrug of zidovudine obtained by its ester conjugation with a bile acid, the ursodeoxycholic acid. The free prodrug was hydrolizated in rat liver homogenates with an half life of 2.7 min, whereas the loaded NP nanoparticles appeared able to significantly stabilize the prodrug in this physiological fluid.
Polymeric nanoparticles for the substained release of a prodrug of zidovudine obtained by its conjugation with the ursodeoxycholic acid / A., Dalpiaz; M., Fogagnolo; D., Perrone; C., Contado; B., Pavan; G., Paganetto; Vighi, Eleonora; Iannuccelli, Valentina; Leo, Eliana Grazia. - STAMPA. - ND:(2012), pp. 83-83. (Intervento presentato al convegno XXII Simposium ADRITELF 2012 tenutosi a Firenze - Italia nel 13-16 settembre 2012).
Polymeric nanoparticles for the substained release of a prodrug of zidovudine obtained by its conjugation with the ursodeoxycholic acid
VIGHI, Eleonora;IANNUCCELLI, Valentina;LEO, Eliana Grazia
2012
Abstract
We report a study of encapsulation and release from PLGA nanoparticles of a prodrug of zidovudine obtained by its ester conjugation with a bile acid, the ursodeoxycholic acid. The free prodrug was hydrolizated in rat liver homogenates with an half life of 2.7 min, whereas the loaded NP nanoparticles appeared able to significantly stabilize the prodrug in this physiological fluid.
Pubblicazioni consigliate
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris
