Here we investigated whether melanocortin peptides, which have protective effects in severe hypoxic conditions, are able to produce neuroprotection in ischemic stroke. Our findings suggest that melanocortins that are agonist at the MC4 receptors may represent a class of drugs with a broad therapeutic window for a new approach to neuroprotection in ischemic stroke
Neuroprotection against ischemic stroke by early or delayed treatment with MC4 receptor-stimulating melanocortins / Giuliani, Daniela; Bazzani, C; Mioni, C; Altavilla, D; Leone, S; Minutoli, L; Bitto, A; Zaffe, D; Botticelli, Ar; Pizzala, R; Ferrari, Anna; Squadrito, F; Bertolini, A; Guarini, Salvatore. - STAMPA. - 32° Congresso Nazionale della Società Italiana di Farmacologia:(2005), pp. 108-108. (Intervento presentato al convegno 32° Congresso Nazionale della Società Italiana di Farmacologia tenutosi a Napoli nel 1-4 giugno 2005).
Neuroprotection against ischemic stroke by early or delayed treatment with MC4 receptor-stimulating melanocortins
GIULIANI, Daniela;FERRARI, Anna;GUARINI, Salvatore
2005
Abstract
Here we investigated whether melanocortin peptides, which have protective effects in severe hypoxic conditions, are able to produce neuroprotection in ischemic stroke. Our findings suggest that melanocortins that are agonist at the MC4 receptors may represent a class of drugs with a broad therapeutic window for a new approach to neuroprotection in ischemic stroke
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