The concentration of benzodiazepines (BDZs) in serum from normal subject resulted under the limit of detection (lower tha 2 nmol DE/l) in 46 cases (51%). In the remaining 44 normal subjects the total amount binding ranged between 6 and 20 nmol DE/l. In the liver cirrhosis BDZs were under the detection limit in 7% of patients withencephalopathy. When detectable, tehi levels were at least comparable with those of benzodiazepines consumers and correlated with the liver dysfuntion but not with the stages of encephlopathy.
Endogenous benzodiazepine-like compounds in serum of normal subjects and in liver cirrhosis patients / I., Venturini; Avallone, Rossella; Corsi, Lorenzo; Zeneroli, Maria Luisa; P., Schreier; M., Kleinschnitz; Farina, Franco; Baraldi, Mario. - STAMPA. - LXIX, suppl.5:(1998), pp. 19-19. (Intervento presentato al convegno Fitoterapia tenutosi a Modena nel 21-24 ottobre 19998).
Endogenous benzodiazepine-like compounds in serum of normal subjects and in liver cirrhosis patients.
AVALLONE, Rossella;CORSI, Lorenzo;ZENEROLI, Maria Luisa;FARINA, Franco;BARALDI, Mario
1998
Abstract
The concentration of benzodiazepines (BDZs) in serum from normal subject resulted under the limit of detection (lower tha 2 nmol DE/l) in 46 cases (51%). In the remaining 44 normal subjects the total amount binding ranged between 6 and 20 nmol DE/l. In the liver cirrhosis BDZs were under the detection limit in 7% of patients withencephalopathy. When detectable, tehi levels were at least comparable with those of benzodiazepines consumers and correlated with the liver dysfuntion but not with the stages of encephlopathy.
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