The behavioral effects of acute administration of chrysin, contained in Passiflora incarnata, were studied in rats. The data demonstrate that in our experimental conditions, chrysin was able to reduce locomotor activity when injected in rats at a minimal effective dose of 25 mgrkg. However, chrysin exhibited a clear anxiolytic effect when injected at the dose of 1 mgrkg,. The sedative effect of the flavonoid cannot be ascribed to an interaction with GABA]benzodiazepine receptors, since it was not counteracted by the benzodiazepine antagonist Flumazenil. To the contrary, the anxiolytic effect of chrysin, which was blocked by the injection of Flumazenil, could be linked to an activation of the GABAA receptor unit.
Sedative and anxiolytic properties od chrysin, a constituent of Passiflora incarnata / Rivasi, Marianna; Muscatello, Cinzia; Zanoli, Paola; Avallone, Rossella; Baraldi, Mario. - STAMPA. - 43 suppl A:(2001), pp. 149-149. (Intervento presentato al convegno XXX Congtersso della Società Italiana di Farmacologia tenutosi a Genova nel 30 maggio - 2 giugno 2001).
Sedative and anxiolytic properties od chrysin, a constituent of Passiflora incarnata
RIVASI, Marianna;MUSCATELLO, Cinzia;ZANOLI, Paola;AVALLONE, Rossella;BARALDI, Mario
2001
Abstract
The behavioral effects of acute administration of chrysin, contained in Passiflora incarnata, were studied in rats. The data demonstrate that in our experimental conditions, chrysin was able to reduce locomotor activity when injected in rats at a minimal effective dose of 25 mgrkg. However, chrysin exhibited a clear anxiolytic effect when injected at the dose of 1 mgrkg,. The sedative effect of the flavonoid cannot be ascribed to an interaction with GABA]benzodiazepine receptors, since it was not counteracted by the benzodiazepine antagonist Flumazenil. To the contrary, the anxiolytic effect of chrysin, which was blocked by the injection of Flumazenil, could be linked to an activation of the GABAA receptor unit.
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