Humulus lupulus (hops) is traditionally used as a tranquilizing herbal remedy. Here, we investigated the in vivo and in vitro effect of hop -acids on central nervous system function. Oral administration of -acids (5–10 mg/kg) in rats produced an increased exploratory activity in the open field, a reduction in the pentobarbital hypnotic activity and a worsening of picrotoxin-induced seizures. When dosed at 10 mg/kg, -acids increased, in the elevated plus maze, open arm entries reducing in parallel those in closed arms. In the forced swimming test, we observed a reduction in the immobility time that could suggest an antidepressant-like activity. Electrophysiological studies performed on cerebellar granule cells in culture showed that the -acids fraction decreased GABA-evoked current in a dose-dependent way. The effect was not inhibited by the benzodiazepine antagonist Ro 15-1788. Benzodiazepine receptors involvement was also excluded by [3H]-Ro 15-1788 binding assay. In conclusion, the behavioraleffects of -acids fraction could be explained by a reduction in the GABAergic activity although we cannot rule out the involvement of other neurotransmitter systems.

Pharmacological characterisation of beta-acids fraction of hops / Zavatti, Manuela; Zanoli, Paola; Rivasi, Marianna; Avallone, Rossella; Baraldi, Mario. - STAMPA. - 1:(2005), pp. 69-69. ((Intervento presentato al convegno 32 Congresso Nazionale della Società Italiana di Farmacologia tenutosi a Napoli nel 1-4 giugno 2005.

Pharmacological characterisation of beta-acids fraction of hops

ZAVATTI, Manuela;ZANOLI, Paola;RIVASI, Marianna;AVALLONE, Rossella;BARALDI, Mario
2005

Abstract

Humulus lupulus (hops) is traditionally used as a tranquilizing herbal remedy. Here, we investigated the in vivo and in vitro effect of hop -acids on central nervous system function. Oral administration of -acids (5–10 mg/kg) in rats produced an increased exploratory activity in the open field, a reduction in the pentobarbital hypnotic activity and a worsening of picrotoxin-induced seizures. When dosed at 10 mg/kg, -acids increased, in the elevated plus maze, open arm entries reducing in parallel those in closed arms. In the forced swimming test, we observed a reduction in the immobility time that could suggest an antidepressant-like activity. Electrophysiological studies performed on cerebellar granule cells in culture showed that the -acids fraction decreased GABA-evoked current in a dose-dependent way. The effect was not inhibited by the benzodiazepine antagonist Ro 15-1788. Benzodiazepine receptors involvement was also excluded by [3H]-Ro 15-1788 binding assay. In conclusion, the behavioraleffects of -acids fraction could be explained by a reduction in the GABAergic activity although we cannot rule out the involvement of other neurotransmitter systems.
32 Congresso Nazionale della Società Italiana di Farmacologia
Napoli
1-4 giugno 2005
Zavatti, Manuela; Zanoli, Paola; Rivasi, Marianna; Avallone, Rossella; Baraldi, Mario
Pharmacological characterisation of beta-acids fraction of hops / Zavatti, Manuela; Zanoli, Paola; Rivasi, Marianna; Avallone, Rossella; Baraldi, Mario. - STAMPA. - 1:(2005), pp. 69-69. ((Intervento presentato al convegno 32 Congresso Nazionale della Società Italiana di Farmacologia tenutosi a Napoli nel 1-4 giugno 2005.
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/741724
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact