Humulus lupulus (hops) is traditionally used as a tranquilizing herbal remedy. Here, we investigated the in vivo and in vitro effect of hop -acids on central nervous system function. Oral administration of -acids (5–10 mg/kg) in rats produced an increased exploratory activity in the open field, a reduction in the pentobarbital hypnotic activity and a worsening of picrotoxin-induced seizures. When dosed at 10 mg/kg, -acids increased, in the elevated plus maze, open arm entries reducing in parallel those in closed arms. In the forced swimming test, we observed a reduction in the immobility time that could suggest an antidepressant-like activity. Electrophysiological studies performed on cerebellar granule cells in culture showed that the -acids fraction decreased GABA-evoked current in a dose-dependent way. The effect was not inhibited by the benzodiazepine antagonist Ro 15-1788. Benzodiazepine receptors involvement was also excluded by [3H]-Ro 15-1788 binding assay. In conclusion, the behavioraleffects of -acids fraction could be explained by a reduction in the GABAergic activity although we cannot rule out the involvement of other neurotransmitter systems.
Pharmacological characterisation of beta-acids fraction of hops / Zavatti, Manuela; Zanoli, Paola; Rivasi, Marianna; Avallone, Rossella; Baraldi, Mario. - STAMPA. - 1(2005), pp. 69-69. ((Intervento presentato al convegno 32 Congresso Nazionale della Società Italiana di Farmacologia tenutosi a Napoli nel 1-4 giugno 2005.
Data di pubblicazione: | 2005 |
Autore/i: | Zavatti, Manuela; Zanoli, Paola; Rivasi, Marianna; Avallone, Rossella; Baraldi, Mario |
Titolo: | Pharmacological characterisation of beta-acids fraction of hops |
Nome del convegno: | 32 Congresso Nazionale della Società Italiana di Farmacologia |
Luogo del convegno: | Napoli |
Data del convegno: | 1-4 giugno 2005 |
Citazione: | Pharmacological characterisation of beta-acids fraction of hops / Zavatti, Manuela; Zanoli, Paola; Rivasi, Marianna; Avallone, Rossella; Baraldi, Mario. - STAMPA. - 1(2005), pp. 69-69. ((Intervento presentato al convegno 32 Congresso Nazionale della Società Italiana di Farmacologia tenutosi a Napoli nel 1-4 giugno 2005. |
Tipologia | Abstract in Atti di Convegno |
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