Non-alcoholic fatty liver disease (NAFLD) is a common cause of chronicliver disease. The NAFLD includes non-alcoholic fatty liver (NAFL) andnon-alcoholic steatohepatitis (NASH). The mechanisms of NAFLD to NASH transition remain to be clarified. NAFLD appears to originate from the dysregulation of hepatic lipid metabolism as a part of the metabolicsyndrome accompanied by visceral obesity dyslipidemia, atherosclerosis, and insulin resistance. High Resolution Magic Angle Spinning (HR-MAS) NMR is a useful tool for the metabolic characterization of intact tissues and can be used to support the clinical diagnosis. The aim of this study is to characterized the NAFLD and NASH metabolism using HR-MAS NMR Spectroscopy, and to evaluate the possible transition from NAFLD to NASH. Liver needle biopsies were collected for the HR-MAS and histological analyses. Preliminary HR-MAS NMR results show a higher amount of lipids in the biopsies from patients with 30-50% of steatosis, whereas lipids and of small metabolites are present when the liver is affected from a market fibrosis.

Non-alcoholic Fatty Liver Disease: a HR-MAS analysis / F., Filace; Righi, Valeria; Stentarelli, Chiara; Guaraldi, Giovanni; V., Borghi; Zona, Stefano; Ligabue, Guido; G., Busetti; Loria, Paola; Ballestri, Stefano; L., Losi; L., Nocetti; Schenetti, Luisa; Mucci, Adele. - STAMPA. - Unico:(2010), pp. 177-177. (Intervento presentato al convegno WWMR2010 - Joint EUROMAR 2010 and 17th ISMAR Conference tenutosi a Firenze nel 4-9 luglio).

Non-alcoholic Fatty Liver Disease: a HR-MAS analysis

RIGHI, VALERIA;STENTARELLI, Chiara;GUARALDI, Giovanni;ZONA, Stefano;LIGABUE, Guido;LORIA, Paola;BALLESTRI, Stefano;SCHENETTI, Luisa;MUCCI, Adele
2010

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a common cause of chronicliver disease. The NAFLD includes non-alcoholic fatty liver (NAFL) andnon-alcoholic steatohepatitis (NASH). The mechanisms of NAFLD to NASH transition remain to be clarified. NAFLD appears to originate from the dysregulation of hepatic lipid metabolism as a part of the metabolicsyndrome accompanied by visceral obesity dyslipidemia, atherosclerosis, and insulin resistance. High Resolution Magic Angle Spinning (HR-MAS) NMR is a useful tool for the metabolic characterization of intact tissues and can be used to support the clinical diagnosis. The aim of this study is to characterized the NAFLD and NASH metabolism using HR-MAS NMR Spectroscopy, and to evaluate the possible transition from NAFLD to NASH. Liver needle biopsies were collected for the HR-MAS and histological analyses. Preliminary HR-MAS NMR results show a higher amount of lipids in the biopsies from patients with 30-50% of steatosis, whereas lipids and of small metabolites are present when the liver is affected from a market fibrosis.
2010
WWMR2010 - Joint EUROMAR 2010 and 17th ISMAR Conference
Firenze
4-9 luglio
F., Filace; Righi, Valeria; Stentarelli, Chiara; Guaraldi, Giovanni; V., Borghi; Zona, Stefano; Ligabue, Guido; G., Busetti; Loria, Paola; Ballestri, Stefano; L., Losi; L., Nocetti; Schenetti, Luisa; Mucci, Adele
Non-alcoholic Fatty Liver Disease: a HR-MAS analysis / F., Filace; Righi, Valeria; Stentarelli, Chiara; Guaraldi, Giovanni; V., Borghi; Zona, Stefano; Ligabue, Guido; G., Busetti; Loria, Paola; Ballestri, Stefano; L., Losi; L., Nocetti; Schenetti, Luisa; Mucci, Adele. - STAMPA. - Unico:(2010), pp. 177-177. (Intervento presentato al convegno WWMR2010 - Joint EUROMAR 2010 and 17th ISMAR Conference tenutosi a Firenze nel 4-9 luglio).
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