Lipospheres for the cosmetic delivery of glycolic acid were prepared by the melt method using tristearin as the lipid phase and hydrogenated soybean phosphatidylcholine as the emulsifier. The most favourable conditions leading to the highest liposphere yield involved triglyceride/phospholipid ratios of 4:1 or 5:1 and a phospholipid concentration of at least 2%. The lipospheres, sized from 5 to 40 micron, contained a rather high glycolic acid loading level probably due to a partial polymorphic modification of the lipid and determined glycolic acid sustained release pattern.
The effect of triglycerid/phospholipid ratio in liposphere preparation / Iannuccelli, Valentina; Coppi, Gilberto; Leo, Eliana Grazia; Cameroni, Riccardo. - ELETTRONICO. - ND:(2000), pp. 6140-6140. (Intervento presentato al convegno 27th International Simposium on Controlled Release of Bioactive Materials tenutosi a Parigi - Francia nel 7-13 luglio 2000).
The effect of triglycerid/phospholipid ratio in liposphere preparation
IANNUCCELLI, Valentina;COPPI, Gilberto;LEO, Eliana Grazia;CAMERONI, Riccardo
2000
Abstract
Lipospheres for the cosmetic delivery of glycolic acid were prepared by the melt method using tristearin as the lipid phase and hydrogenated soybean phosphatidylcholine as the emulsifier. The most favourable conditions leading to the highest liposphere yield involved triglyceride/phospholipid ratios of 4:1 or 5:1 and a phospholipid concentration of at least 2%. The lipospheres, sized from 5 to 40 micron, contained a rather high glycolic acid loading level probably due to a partial polymorphic modification of the lipid and determined glycolic acid sustained release pattern.
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