Calcium alginate floating units loaded with tetracycline were prepared by means an interfacial crosslinking reaction of sodium alginate drops with calcium ions and freeze-drying providing porous units with apparent density values less than that of the gastric juice. Such a technological approach has simplified a previous manufacture for the development of calcium alginate air-compartment floating units which showed actual buoyancy properties and prolonged Gastric Residence Time (GRT) in human trials in fed conditions. The formulation study provided a sample with optimum property in terms of drug loading level for the treatment of Helicobacter pylori infection.
Gastroretentive multiple-unit delivery system in the treatment of Helicobacter pylori infection / Iannuccelli, Valentina; Romagnoli, Marcello; Sergi, Santo; Coppi, Gilberto. - ELETTRONICO. - ND:(2007), pp. ND-ND. (Intervento presentato al convegno PSWC 2007 Meeting tenutosi a Amsterdam nel 22/25 aprile 2007).
Gastroretentive multiple-unit delivery system in the treatment of Helicobacter pylori infection
IANNUCCELLI, Valentina;ROMAGNOLI, Marcello;SERGI, Santo;COPPI, Gilberto
2007
Abstract
Calcium alginate floating units loaded with tetracycline were prepared by means an interfacial crosslinking reaction of sodium alginate drops with calcium ions and freeze-drying providing porous units with apparent density values less than that of the gastric juice. Such a technological approach has simplified a previous manufacture for the development of calcium alginate air-compartment floating units which showed actual buoyancy properties and prolonged Gastric Residence Time (GRT) in human trials in fed conditions. The formulation study provided a sample with optimum property in terms of drug loading level for the treatment of Helicobacter pylori infection.
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