POLYMER CONJUGATES OF K-252A AND DERIVATIVES THEREOF

Traversa, S.; Bagnod, R.; Barone, D.; Beratarione Rava Rossa, L.; Fumero, S.; Mainero, V.; Marconi, A.; Oderda, C.; Pincelli, C.; Lorenzetto, C.; Beccaria, L.

The present invention relates to novel polymer conjugates of K-252a and derivatives thereof and to their use for the preparation of a pharmaceutical composition useful for the prevention, alleviation and treatment of kinase-associated pathologies. In particular, the present invention relates to the prevention, alleviation and treatment of HMGB1-associated pathologies. In a particular aspect, the invention relates to the use of the novel polymer conjugates of K-252a and derivatives thereof in the preparation of a pharmaceutical composition useful for the prevention, alleviation and treatment of neurological disorders, neuropathies and neurodegenerative disorders of the central and peripheral nervous system.; In a further preferred aspect, the invention relates to the use of the polymer conjugates in the preparation of a pharmaceutical composition useful for the prevention, alleviation and treatment of dermal pathologies, in particular dermal pathologies associated with an excessive keratinocyte proliferation, in particular psoriasis. In a still further aspect, the invention relates to the use of the polymer conjugates in the prevention, alleviation and treatment of NGF-related pain. More specifically, the present invention relates to a polymer conjugate of K-252a and derivatives thereof, wherein the polymer is polyethylene glycol or methoxy-polyethylene glycol formula.

Data di pubblicazione:	25-ago-2005
Titolo:	POLYMER CONJUGATES OF K-252A AND DERIVATIVES THEREOF
Autore/i:	Traversa, S.; Bagnod, R.; Barone, D.; Beratarione Rava Rossa, L.; Fumero, S.; Mainero, V.; Marconi, A.; Oderda, C.; Pincelli, C.; Lorenzetto, C.; Beccaria, L.
Autore/i UNIMORE:	S. Traversa R. Bagnod D. Barone L. Beratarione Rava Rossa S. Fumero V. Mainero MARCONI, Alessandra C. Oderda PINCELLI, Carlo C. Lorenzetto L. Beccaria mostra contributor esterni nascondi contributor esterni
Handle:	http://hdl.handle.net/11380/593346
Enti collegati:	CREABILIS THERAPEUTICS S P A [IT]; TRAVERSA SILVIO [IT]; BAGNOD RAFFAELLA [IT]; BARONE DOMENICO [IT]; BERTARIONE RAVA ROSSA LUISA [IT]; FUMERO SILVANO [IT]; MAINERO VALENTINA [IT]; MARCONI ALESSANDRA [IT]; ODERDA CECILIA [CH]; PINCELLI CARLO [IT]; LORENZETTO CHIARA [IT]; BECCARIA LUCA [IT]
Rilevanza:	Internazionale
Numero di deposito:	WO2007022999
Tipologia	Brevetto

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