The present invention relates to novel polymer conjugates of K-252a and derivatives thereof and to their use for the preparation of a pharmaceutical composition useful for the prevention, alleviation and treatment of kinase-associated pathologies. In particular, the present invention relates to the prevention, alleviation and treatment of HMGB1-associated pathologies. In a particular aspect, the invention relates to the use of the novel polymer conjugates of K-252a and derivatives thereof in the preparation of a pharmaceutical composition useful for the prevention, alleviation and treatment of neurological disorders, neuropathies and neurodegenerative disorders of the central and peripheral nervous system.; In a further preferred aspect, the invention relates to the use of the polymer conjugates in the preparation of a pharmaceutical composition useful for the prevention, alleviation and treatment of dermal pathologies, in particular dermal pathologies associated with an excessive keratinocyte proliferation, in particular psoriasis. In a still further aspect, the invention relates to the use of the polymer conjugates in the prevention, alleviation and treatment of NGF-related pain. More specifically, the present invention relates to a polymer conjugate of K-252a and derivatives thereof, wherein the polymer is polyethylene glycol or methoxy-polyethylene glycol formula.

POLYMER CONJUGATES OF K-252A AND DERIVATIVES THEREOF / Traversa, S.; Bagnod, R.; Barone, D.; Beratarione Rava Rossa, L.; Fumero, S.; Mainero, V.; Marconi, A.; Oderda, C.; Pincelli, C.; Lorenzetto, C.; Beccaria, L.. - (2005 Aug 25).

POLYMER CONJUGATES OF K-252A AND DERIVATIVES THEREOF

A. Marconi;C. Pincelli;
2005

Abstract

The present invention relates to novel polymer conjugates of K-252a and derivatives thereof and to their use for the preparation of a pharmaceutical composition useful for the prevention, alleviation and treatment of kinase-associated pathologies. In particular, the present invention relates to the prevention, alleviation and treatment of HMGB1-associated pathologies. In a particular aspect, the invention relates to the use of the novel polymer conjugates of K-252a and derivatives thereof in the preparation of a pharmaceutical composition useful for the prevention, alleviation and treatment of neurological disorders, neuropathies and neurodegenerative disorders of the central and peripheral nervous system.; In a further preferred aspect, the invention relates to the use of the polymer conjugates in the preparation of a pharmaceutical composition useful for the prevention, alleviation and treatment of dermal pathologies, in particular dermal pathologies associated with an excessive keratinocyte proliferation, in particular psoriasis. In a still further aspect, the invention relates to the use of the polymer conjugates in the prevention, alleviation and treatment of NGF-related pain. More specifically, the present invention relates to a polymer conjugate of K-252a and derivatives thereof, wherein the polymer is polyethylene glycol or methoxy-polyethylene glycol formula.
CREABILIS THERAPEUTICS S P A [IT]; TRAVERSA SILVIO [IT]; BAGNOD RAFFAELLA [IT]; BARONE DOMENICO [IT]; BERTARIONE RAVA ROSSA LUISA [IT]; FUMERO SILVANO [IT]; MAINERO VALENTINA [IT]; MARCONI ALESSANDRA [IT]; ODERDA CECILIA [CH]; PINCELLI CARLO [IT]; LORENZETTO CHIARA [IT]; BECCARIA LUCA [IT]
WO2007022999
Internazionale
Traversa, S.; Bagnod, R.; Barone, D.; Beratarione Rava Rossa, L.; Fumero, S.; Mainero, V.; Marconi, A.; Oderda, C.; Pincelli, C.; Lorenzetto, C.; Beccaria, L.
File in questo prodotto:
File Dimensione Formato  
WO2007022999A1.pdf

accesso aperto

Tipologia: Altro materiale allegato
Dimensione 3.38 MB
Formato Adobe PDF
3.38 MB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/593346
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact