Disclosed is a peptide comprising the sequence: H2N-Gly-Phe-D-Thr-Gly-Phe-Leu-Ser-CONH2, wherein the serine residue may be functionalized with sugar residues; other aminoacids can replace the first 2 amino acids of the N-terminal portion, the order of which can be reversed, and their no. may be different from 2. Thus, a data anal. obtained from the in vivo study with fluorescence microscopy clearly shows that the nanoparticles obtained with PLGA modified with the peptide H2N-Gly-Phe-D-Thr-Gly-Phe-Leu-Ser-CONH2, and to a greater extent with the peptide H2N-Gly-Phe-D-Thr-Gly-Phe-Leu-SerO-.beta.-D-glucose-CONH2 are able to cross the BBB and penetrate into the brain parenchyma. However, the nanoparticles only constituted by PLGA are unable to cross the blood-brain barrier, and remain in the blood vessels.

Drug Delivery Peptides / Costantino, Luca; Forni, Flavio; Vandelli, Maria Angela. - .

Drug Delivery Peptides

COSTANTINO, Luca;FORNI, Flavio;VANDELLI, Maria Angela

Abstract

Disclosed is a peptide comprising the sequence: H2N-Gly-Phe-D-Thr-Gly-Phe-Leu-Ser-CONH2, wherein the serine residue may be functionalized with sugar residues; other aminoacids can replace the first 2 amino acids of the N-terminal portion, the order of which can be reversed, and their no. may be different from 2. Thus, a data anal. obtained from the in vivo study with fluorescence microscopy clearly shows that the nanoparticles obtained with PLGA modified with the peptide H2N-Gly-Phe-D-Thr-Gly-Phe-Leu-Ser-CONH2, and to a greater extent with the peptide H2N-Gly-Phe-D-Thr-Gly-Phe-Leu-SerO-.beta.-D-glucose-CONH2 are able to cross the BBB and penetrate into the brain parenchyma. However, the nanoparticles only constituted by PLGA are unable to cross the blood-brain barrier, and remain in the blood vessels.
2006
Università di Modena e Reggio Emilia
WO2006/061101
Internazionale
Costantino, Luca; Forni, Flavio; Vandelli, Maria Angela
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/467718
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