Nelfinavir (NFV) pharmacokinetics (PK) was evaluated in a cohort of HIV+/HCV+ pts with different degrees of liver impairment and compared to HIV+/HCV- controls. Group I included 21 HIV+/HCV+pts, while Group II was composed of 42 HIV+/HCV- subjects with normal ALT levels. NFV-PK was determined at steady state. Blood samples for PK analysis were obtained during a dosing interval (≥7 samples per patient). NFV and metabolite M8 plasma concentrations were determined simultaneously by a validated HPLC method.
HCV coinfection with normal or low grade ALT modifies nelfinavir disposition in HIV-positive patients / R., M., P., V., M., C., M. B., R., P., Z., L., S., A., C., Guaraldi, G., C., C., D., G., L., S., M. C., R., P., C.. - STAMPA. - not applicable:(2002), pp. 166-166. (Sixth International Congress on Drug Therapy in HIV Infection Glasgow, UK 17- 21 November 2002).
HCV coinfection with normal or low grade ALT modifies nelfinavir disposition in HIV-positive patients
GUARALDI, Giovanni;
2002
Abstract
Nelfinavir (NFV) pharmacokinetics (PK) was evaluated in a cohort of HIV+/HCV+ pts with different degrees of liver impairment and compared to HIV+/HCV- controls. Group I included 21 HIV+/HCV+pts, while Group II was composed of 42 HIV+/HCV- subjects with normal ALT levels. NFV-PK was determined at steady state. Blood samples for PK analysis were obtained during a dosing interval (≥7 samples per patient). NFV and metabolite M8 plasma concentrations were determined simultaneously by a validated HPLC method.
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