The present invention pertains generally to the field of organic chemical synthesis, and in particular to certain methods for the synthesis of 8-(4-aminophenyoxy)-4H pyrido2.3-bipyrazin-3-one and related compounds (de noted herein as (3)) from 4-(4-aminophenyoxy)pyridine-2, 3-diamine and related compounds (denoted herein as (1)), by reaction with glyoxylic acid (denoted herein as (2)). The compounds (3) are useful in the synthesis of known anti cancer agents, such as 1-(5-tert-butyl-2-(4-methyl-phenyl)- pyrazol-3-yl)-3-2-fluoro-4-(3-oxo-4H-pyrido 2,3-b pyrazin-8-yl)oxyphenylurea.
PROCESS FOR THE PREPARATION OF 8-(4-AMINOPHENOXY)-4H PYRIDO2,3-B PYRAZIN-3-ONE DERIVATIVES / Zambon, Alfonso; Niculescu-Duvaz, Dan; Chubb, Richard; Springer, Caroline Joy. - (2014 Nov 25).
PROCESS FOR THE PREPARATION OF 8-(4-AMINOPHENOXY)-4H PYRIDO2,3-B PYRAZIN-3-ONE DERIVATIVES
Zambon, Alfonso;
2014
Abstract
The present invention pertains generally to the field of organic chemical synthesis, and in particular to certain methods for the synthesis of 8-(4-aminophenyoxy)-4H pyrido2.3-bipyrazin-3-one and related compounds (de noted herein as (3)) from 4-(4-aminophenyoxy)pyridine-2, 3-diamine and related compounds (denoted herein as (1)), by reaction with glyoxylic acid (denoted herein as (2)). The compounds (3) are useful in the synthesis of known anti cancer agents, such as 1-(5-tert-butyl-2-(4-methyl-phenyl)- pyrazol-3-yl)-3-2-fluoro-4-(3-oxo-4H-pyrido 2,3-b pyrazin-8-yl)oxyphenylurea.File | Dimensione | Formato | |
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ProcessPatent.pdf
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ProcessPatentIssue.pdf
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ProcessPatentI_decision.pdf
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