This invention relates to compounds useful as lysyl oxidase (LOX) and lysyl oxidase-like (LOXL) family member (LOXL1, LOXL2, LOXL3, LOXL4) inhibitors. In addition there are contemplated pharmaceutical compositions comprising the compounds and the use of the compounds in the treatment of conditions mediated by LOX and LOXL, for example cancer. In particular a LOX inhibitor such as the present compounds may be for use in the treatment of a cancer associated with EGFR. The present invention also contemplates the identification of biomarkers that predict responsiveness to a LOX inhibitor.

LYSYL OXIDASE INHIBITORS / Marais, Richard; Springer, Caroline; NICULESCU-DUVAZ, Dan; Miller, Natalie; Aljarah, Mohammed; Zambon, Alfonso; Leung, Leo; Smithen, Deborah; Brown, Michael; Tang, Haoran. - (2017 Oct 13).

LYSYL OXIDASE INHIBITORS

ZAMBON, Alfonso;
2017

Abstract

This invention relates to compounds useful as lysyl oxidase (LOX) and lysyl oxidase-like (LOXL) family member (LOXL1, LOXL2, LOXL3, LOXL4) inhibitors. In addition there are contemplated pharmaceutical compositions comprising the compounds and the use of the compounds in the treatment of conditions mediated by LOX and LOXL, for example cancer. In particular a LOX inhibitor such as the present compounds may be for use in the treatment of a cancer associated with EGFR. The present invention also contemplates the identification of biomarkers that predict responsiveness to a LOX inhibitor.
13-ott-2017
18-apr-2019
THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL
WO/2019/073251
Internazionale
Marais, Richard; Springer, Caroline; NICULESCU-DUVAZ, Dan; Miller, Natalie; Aljarah, Mohammed; Zambon, Alfonso; Leung, Leo; Smithen, Deborah; Brown, Michael; Tang, Haoran
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1176723
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