The invention relates to means and methods of targeted drug delivery of therapeutic agent to and across the blood-ocular barrier. In particular, the invention relates to cyclic guanosine-3', 5 '-monophosphate analogues as therapeutic agent for treating retinal diseases. The cGMPSs targeted to the blood-ocular barrier by glutathione-based ligands that facilitate the specific binding to and enhanced internalization by glutathione transporters present on the blood-ocular barrier. The glutathione-based ligands are conjugated to nanocontainers such as liposomes encapsulating the cGMPSs.
Targeted liposomal delivery of cGMP analogues / Per, Ekström; François, PAQUET-DURAND; Pieter Jaap, Gaillard; Marigo, Valeria; Hans-Gottfried, Genieser; Andreas, Rentsch. - (2017 Sep 09).
Data di pubblicazione: | 9-set-2017 | |
Data di concessione: | 2019-02-06 | |
Titolo: | Targeted liposomal delivery of cGMP analogues | |
Autore/i: | Per, Ekström; François, PAQUET-DURAND; Pieter Jaap, Gaillard; Marigo, Valeria; Hans-Gottfried, Genieser; Andreas, Rentsch | |
Autore/i UNIMORE: | ||
Abstract: | The invention relates to means and methods of targeted drug delivery of therapeutic agent to and across the blood-ocular barrier. In particular, the invention relates to cyclic guanosine-3', 5 '-monophosphate analogues as therapeutic agent for treating retinal diseases. The cGMPSs targeted to the blood-ocular barrier by glutathione-based ligands that facilitate the specific binding to and enhanced internalization by glutathione transporters present on the blood-ocular barrier. The glutathione-based ligands are conjugated to nanocontainers such as liposomes encapsulating the cGMPSs. | |
Handle: | http://hdl.handle.net/11380/1174125 | |
Enti collegati: | Mireca Medicine GmbH | |
Rilevanza: | Internazionale | |
Numero di deposito: | WO2016146669A1 | |
Tipologia | Brevetto |
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