Targeted liposomal delivery of cGMP analogues

Per, Ekström; François, Paquet-Durand; Pieter Jaap GAILLARD,; Marigo, Valeria; Hans-Gottfried, Genieser; Andreas, Rentsch

The invention relates to means and methods of targeted drug delivery of therapeutic agent to and across the blood-ocular barrier. In particular, the invention relates to cyclic guanosine-3', 5 '-monophosphate analogues as therapeutic agent for treating retinal diseases. The cGMPSs targeted to the blood-ocular barrier by glutathione-based ligands that facilitate the specific binding to and enhanced internalization by glutathione transporters present on the blood-ocular barrier. The glutathione-based ligands are conjugated to nanocontainers such as liposomes encapsulating the cGMPSs.

Targeted liposomal delivery of cGMP analogues / Per, Ekström; François, PAQUET-DURAND; Pieter Jaap, Gaillard; Marigo, Valeria; Hans-Gottfried, Genieser; Andreas, Rentsch. - (2017 Sep 09).

Data di pubblicazione:	9-set-2017
Data di concessione:	2019-02-06
Titolo:	Targeted liposomal delivery of cGMP analogues
Autore/i:	Per, Ekström; François, PAQUET-DURAND; Pieter Jaap, Gaillard; Marigo, Valeria; Hans-Gottfried, Genieser; Andreas, Rentsch
Autore/i UNIMORE:	Per EKSTRÖM François PAQUET-DURAND Pieter Jaap GAILLARD MARIGO, Valeria Hans-Gottfried GENIESER Andreas RENTSCH mostra contributor esterni nascondi contributor esterni
Abstract:	The invention relates to means and methods of targeted drug delivery of therapeutic agent to and across the blood-ocular barrier. In particular, the invention relates to cyclic guanosine-3', 5 '-monophosphate analogues as therapeutic agent for treating retinal diseases. The cGMPSs targeted to the blood-ocular barrier by glutathione-based ligands that facilitate the specific binding to and enhanced internalization by glutathione transporters present on the blood-ocular barrier. The glutathione-based ligands are conjugated to nanocontainers such as liposomes encapsulating the cGMPSs.
Handle:	http://hdl.handle.net/11380/1174125
Enti collegati:	Mireca Medicine GmbH
Rilevanza:	Internazionale
Numero di deposito:	WO2016146669A1
Tipologia	Brevetto

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http://hdl.handle.net/11380/1174125

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