IBD patients with NAFLD seem to be younger than the general population is, and they develop it independently from the presence of an altered metabolic profile/metabolic syndrome or of active gut disease; indeed, only the presence of elevated GGT seems to predict the presence of NASH in such group. This could be possibly due to the altered composition of gut microbiota, which characterises IBD itself and/or of a leak in the barrier function, leading in a breakdown of the gut/liver axis.
Inflammatory bowel disease patients seem to develop non-alcoholic steatohepatitis (NASH) independently from an altered metabolic profile or active bowel disease / Sartini, A.; Bianchini, M.; Gitto, S.; Di Girolamo, M.; Bertani, A.; Merighi, A.; Villa, E.. - In: JOURNAL OF CROHN'S AND COLITIS. - ISSN 1873-9946. - 10:(2016), pp. 100-100.