We describe the synthesis and optimisation of a series of new inhibitors of BRAF, a kinase whose mutant form (V600E) is implicated in several types of cancer, with particularly high frequency in melanoma. We designed and synthesised type II inhibitors interacting with the inactive conformation of the V600EBRAF.

The discovery of novel, highly potent inhibitors of BRAF / Niculescu Duvaz, I.; Menard, D; Niculescu Duvaz, D.; Zambon, Alfonso; Davies, L; Preece, N.; Kirk, R.; Whittaker, S.; Marais, R.; Springer, C.. - In: EUROPEAN JOURNAL OF CANCER. - ISSN 0959-8049. - 8:7(2010), pp. 139-139. [10.1016/S1359-6349(10)72148-0]

The discovery of novel, highly potent inhibitors of BRAF

ZAMBON, Alfonso;
2010

Abstract

We describe the synthesis and optimisation of a series of new inhibitors of BRAF, a kinase whose mutant form (V600E) is implicated in several types of cancer, with particularly high frequency in melanoma. We designed and synthesised type II inhibitors interacting with the inactive conformation of the V600EBRAF.
2010
Niculescu Duvaz, I.; Menard, D; Niculescu Duvaz, D.; Zambon, Alfonso; Davies, L; Preece, N.; Kirk, R.; Whittaker, S.; Marais, R.; Springer, C....espandi
The discovery of novel, highly potent inhibitors of BRAF / Niculescu Duvaz, I.; Menard, D; Niculescu Duvaz, D.; Zambon, Alfonso; Davies, L; Preece, N.; Kirk, R.; Whittaker, S.; Marais, R.; Springer, C.. - In: EUROPEAN JOURNAL OF CANCER. - ISSN 0959-8049. - 8:7(2010), pp. 139-139. [10.1016/S1359-6349(10)72148-0]
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1138752
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? 0
social impact