Biotechnological Approaches to Produce Phenylpropanoids in Controlled Conditions

.Plants synthesize an array of natural products based on the phenylpropane skeleton which have multiple functions, highlighting their antioxidant properties adding values to the nutraceutical, pharmaceutical and cosmetology industries, between others. This paper take attention to four biotechnology advances towards make efficient the production of these secondary metabolites. I.- Design and development of efficient methodologies for plant cultures in Temporary Immersion Bioreactors (TIBs); II.- Management of the in vitro photosynthesis to reach photomixotrophic plant cultures; III.- Elicitation of the phenylpropanoids pathway during in vitro cultures; IV.- Polyploidy induction as a biotechnological tool for plant genetic improvement. The model species have been commercial genotypes of blueberries (Vaccinium corymbosum), raspberries (Rubus idaeus) and maqui (Aristotelia chilensis) and, the phenylpropanoids metabolites have been determined indistinctively in biomass and culture medium from both in vitro and ex vitro plantlets. Perspectives in the industrialization of the phenylpropanoids production as a circular bioeconomic process are discussed