For a strategy based on inhalation therapy for tuberculosis by a Dry Powder Inhaler (DPI) device, powder physical properties play a crucial role on powder deposition onto alveolar epithelium and macrophage phagocytosis. The study aimed to assess the role of parameters involved in freeze-drying process of Solid Lipid Microparticles (SLM) loaded with rifampicin, a first-line anti-TB drug. Excellent breathability in terms of both emitted dose (∼95%) and breathable fraction (∼90%), better than that obtained by cryoprotectants, was achieved by sample water dilution and freezing at a very low temperature before freeze-drying. These results indicate the relevant role of the ice crystal structure on SLM aggregation for a superior DPI performance.
The improvement of Solid Lipid Microparticle breathability for an anti-TB inhalation therapy / Maretti, Eleonora; Eleonora, Porcheddu; Leo, Eliana Grazia; Edurne, Imbuluzqueta; Francesca, Buttini; Giulia, Balducci Anna; Sacchetti, Francesca; Iannuccelli, Valentina. - (2015). (Intervento presentato al convegno 42nd CRS Annual Meeting & Exposition tenutosi a Edinburgh, Scotland nel July 26-29, 2015).
The improvement of Solid Lipid Microparticle breathability for an anti-TB inhalation therapy
MARETTI, ELEONORA;LEO, Eliana Grazia;SACCHETTI, FRANCESCA;IANNUCCELLI, Valentina
2015
Abstract
For a strategy based on inhalation therapy for tuberculosis by a Dry Powder Inhaler (DPI) device, powder physical properties play a crucial role on powder deposition onto alveolar epithelium and macrophage phagocytosis. The study aimed to assess the role of parameters involved in freeze-drying process of Solid Lipid Microparticles (SLM) loaded with rifampicin, a first-line anti-TB drug. Excellent breathability in terms of both emitted dose (∼95%) and breathable fraction (∼90%), better than that obtained by cryoprotectants, was achieved by sample water dilution and freezing at a very low temperature before freeze-drying. These results indicate the relevant role of the ice crystal structure on SLM aggregation for a superior DPI performance.
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