AIELLO, DANIELE
AIELLO, DANIELE
Dipartimento di Scienze della Vita
A toolbox of biophysical and analytical assays helps to confirm the activity of novel hTS dimer disrupters (Ddis) with anticancer properties
2022 Tagliazucchi, Lorenzo; Venturelli, Alberto; Malpezzi, Giulia; Moschella, MARIA GAETANA; Aiello, Daniele; Lopresti, Ludovica; Pozzi, Cecilia; Marverti, Gaetano; D'Arca, Domenico; Ponterini, Glauco; Costi, Maria Paola
Advancing sustainable drug development: comparative preclinical study of H80 and Miltefosine using imaging and proteomics
2024 Malpezzi, Giulia; Di Persio, Sara; Tagliazucchi, Lorenzo; Aiello, Daniele; Venturelli, Alberto; Cordeiro-da-Silva, Anabela; Santarem, Nuno; Ponterini, Glauco; Costi, Maria Paola
Applying optical tweezers technology to reveal Thymidylate Synthase interactions with its consensus mRNA
2023 Malpezzi, Giulia; Viader, Xvaier; Zaltron, Annamaria; Neri, Benedetta; di Felice, Giulia; Tagliazucchi, Lorenzo; Aiello, Daniele; Moschella, MARIA GAETANA; Costi, Maria Paola; D'Arca, Domenico; Cecconi, Ciro
Deciphering Host–Parasite Interplay in Leishmania Infection through a One Health View of Proteomics Studies on Drug Resistance
2024 Tagliazucchi, Lorenzo; Pinetti, Diego; Genovese, Filippo; Malpezzi, Giulia; Perea Martinez, Ana; Manzano, José I.; García-Hernández, Raquel; Cole, Alexander R.; Kwon, Ba Reum; Aiello, Daniele; Brooks, Bryan W.; Thoré, Eli S. J.; Bertram, Michael G.; Gamarro, Francisco; Costi, Maria Paola
design, synthesis and biological evaluation of novel YAP:TEAD complex disruptors for thetreatment of colorectal cancer
2023 Tagliazucchi, Lorenzo; Venturelli, Alberto; Malpezzi, Giulia; Zappaterra, Dana; Aiello, Daniele; Elisi, GIAN MARCO; Mor, Marco; Moschella, MARIA GAETANA; Marverti, Gaetano; D'Arca, Domenico; Ponterini, Glauco; Costi, Maria Paola
Development of a novel class of YAP:TEAD interface-3 molecular disruptors to treat colorectal carcinoma
2023 Tagliazucchi, Lorenzo; Malpezzi, Giulia; Aiello, Daniele; Zappaterra, Dana; Elisi, GIAN MARCO; Venturelli, Alberto; Moschella, MARIA GAETANA; D'Arca, Domenico; Marverti, Gaetano; Lopresti, Ludovica; Pozzi, Cecilia; Pacifico, Salvatore; Guerrini, Remo; Ponterini, Glauco; Costi, Maria Paola
Exploiting Forster Resonance Energy Transfer (FRET) in the characterization of YAP:TEAD complex disruption
2022 Tagliazucchi, Lorenzo; Rossi, Marianna; Malpezzi, Giulia; Zappaterra, Dana; Aiello, Daniele; Pozzi, Cecilia; Pacifico, Salvatore; Guerrini, Remo; Venturelli, Alberto; Ponterini, Glauco; Costi, Maria Paola
Exploiting the Optical Tweezer technology to reveal thymidylate synthase interactions with its consensus mRNA
2023 Malpezzi, Giulia; Viander, Xavier; Zaltron, Annamaria; Neri, Benedetta; Di Felice, Giulia; Tagliazucchi, Lorenzo; Aiello, Daniele; Moschella, MARIA GAETANA; Costi, Maria Paola; D'Arca, Domenico; Cecconi, Ciro
EXPLOITING THE OPTICAL TWEEZER, A SINGLE MOLECULE TECHNOLOGY, TO REVEAL THYMIDYLATE SYNTHASE INTERACTIONS WITH ITS CONSENSUS mRNA
2023 Malpezzi, Giulia; Viander, Xavier; Zaltron, Annamaria; Neri, Benedetta; Di Felice, Giulia; Tagliazucchi, Lorenzo; Aiello, Daniele; Moschella, Maria; Costi, Maria Paola; D’Arcae, Domenico; Cecconi, Ciro
Exploring thymidylate synthase mRNA binding site 1 and human TS protein interaction with optical tweezers and bicistronic expression assay
2024 Malpezzi, Giulia; Viander, Xavier; Zaltron, Annamaria; Tagliazucchi, Lorenzo; Aiello, Daniele; D’Arca, Domenico; Cecconi, Ciro; Costi, Maria Paola
Expression, purification, and characterization of Transcriptional Enhancer Associated Domain (hTEAD4), a promising target for anticancer agents
2022 Tagliazucchi, L; Rossi, Marianna; Pozzi, Cecilia; Lopresti, Ludovica; Aiello, D; Venturelli, A; Ponterini, G; Costi, Mp
Intersite Communication in Dimeric Enzymes Highlighted by Structural and Thermodynamic Analysis of Didansyltyrosine Binding to Thymidylate Synthases
2024 Costi, Maria Paola; Venturelli, Alberto; Guaitoli, Giambattista; Vanossi, Davide; Saitta, Francesca; Fessas, Dimitrios; Vitiello, Simone; Malpezzi, Giulia; Aiello, Daniele; Ferrari, Stefania; Tondi, Donatella; Ponterini, Glauco; Costi, Maria Paola
Investigating the mechanism of action of the antiparasitic agent H80 through imaging techniques
2023 Malpezzi, Giulia; Tagliazucchi, Lorenzo; Aiello, Daniele; Venturelli, Alberto; CORDEIRO DA SILVA, Anabela; Santarem, Nuno; Ponterini, Glauco; Costi, Maria Paola
Lead optimization of human thymidylate synthase dimer disrupters: from computational studies to evaluation of their biological profiles
2023 Aiello, Daniele; Malpezzi, Giulia; Tagliazucchi, Lorenzo; Moschella, MARIA GAETANA; Giulia, Saporito; Venturelli, Alberto; Gluaco, Ponterini; D'Arca, Domenico; Marverti, Gaetano; Federico, Falchi; Costi, Maria Paola
Lead-optimization process and characterization of the dissociative effect applied to new dimer disrupters of human Thymidylate Synthase
2022 Aiello, Daniele; Ascione, Cristian; Tagliazucchi, Lorenzo; Malpezzi, Giulia; Cassanelli, Valentina; Ponterini, Glauco; D'Arca, Domenico; Marverti, Gaetano; Moschella, MARIA GAETANA; Falchi, Federico; Venturelli, Alberto; Costi, Maria Paola
One Health Approach in Drug Discovery for Leishmaniasis by Targeting Calpain cys-protease.
2024 Aiello, Daniele; Tagliazucchi, Lorenzo; Malpezzi, Giulia; Mazzorana, Marco; Pozzi, Cecilia; Brancale, Andrea; Costi, Maria Paola
Optimization of chemical-biological tools for characterizing the activity of dissociative inhibitor of human thymidylate synthase
2024 Saporito, Giulia; Aiello, Daniele; Malpezzi, Giulia; Tagliazucchi, Lorenzo; Venturelli, Alberto; Falchi, Federico; Ponterini, Glauco; Costi, Maria Paola
Preclinical investigation of H80 compared to miltefosine: imaging and proteomics for sustainable drug development
2024 Malpezzi, Giulia; Tagliazucchi, Lorenzo; Aiello, Daniele; Venturelli, Alberto; Cordeiro-da-Silva, Anabela; Santarem, Nuno; Ponterini, Glauco; Costi, Maria Paola
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| A toolbox of biophysical and analytical assays helps to confirm the activity of novel hTS dimer disrupters (Ddis) with anticancer properties | 1-gen-2022 | Tagliazucchi, Lorenzo; Venturelli, Alberto; Malpezzi, Giulia; Moschella, MARIA GAETANA; Aiello, Daniele; Lopresti, Ludovica; Pozzi, Cecilia; Marverti, Gaetano; D'Arca, Domenico; Ponterini, Glauco; Costi, Maria Paola | |
| Advancing sustainable drug development: comparative preclinical study of H80 and Miltefosine using imaging and proteomics | 1-gen-2024 | Malpezzi, Giulia; Di Persio, Sara; Tagliazucchi, Lorenzo; Aiello, Daniele; Venturelli, Alberto; Cordeiro-da-Silva, Anabela; Santarem, Nuno; Ponterini, Glauco; Costi, Maria Paola | |
| Applying optical tweezers technology to reveal Thymidylate Synthase interactions with its consensus mRNA | 1-gen-2023 | Malpezzi, Giulia; Viader, Xvaier; Zaltron, Annamaria; Neri, Benedetta; di Felice, Giulia; Tagliazucchi, Lorenzo; Aiello, Daniele; Moschella, MARIA GAETANA; Costi, Maria Paola; D'Arca, Domenico; Cecconi, Ciro | |
| Deciphering Host–Parasite Interplay in Leishmania Infection through a One Health View of Proteomics Studies on Drug Resistance | 1-gen-2024 | Tagliazucchi, Lorenzo; Pinetti, Diego; Genovese, Filippo; Malpezzi, Giulia; Perea Martinez, Ana; Manzano, José I.; García-Hernández, Raquel; Cole, Alexander R.; Kwon, Ba Reum; Aiello, Daniele; Brooks, Bryan W.; Thoré, Eli S. J.; Bertram, Michael G.; Gamarro, Francisco; Costi, Maria Paola | |
| design, synthesis and biological evaluation of novel YAP:TEAD complex disruptors for thetreatment of colorectal cancer | 1-gen-2023 | Tagliazucchi, Lorenzo; Venturelli, Alberto; Malpezzi, Giulia; Zappaterra, Dana; Aiello, Daniele; Elisi, GIAN MARCO; Mor, Marco; Moschella, MARIA GAETANA; Marverti, Gaetano; D'Arca, Domenico; Ponterini, Glauco; Costi, Maria Paola | |
| Development of a novel class of YAP:TEAD interface-3 molecular disruptors to treat colorectal carcinoma | 1-gen-2023 | Tagliazucchi, Lorenzo; Malpezzi, Giulia; Aiello, Daniele; Zappaterra, Dana; Elisi, GIAN MARCO; Venturelli, Alberto; Moschella, MARIA GAETANA; D'Arca, Domenico; Marverti, Gaetano; Lopresti, Ludovica; Pozzi, Cecilia; Pacifico, Salvatore; Guerrini, Remo; Ponterini, Glauco; Costi, Maria Paola | |
| Exploiting Forster Resonance Energy Transfer (FRET) in the characterization of YAP:TEAD complex disruption | 1-gen-2022 | Tagliazucchi, Lorenzo; Rossi, Marianna; Malpezzi, Giulia; Zappaterra, Dana; Aiello, Daniele; Pozzi, Cecilia; Pacifico, Salvatore; Guerrini, Remo; Venturelli, Alberto; Ponterini, Glauco; Costi, Maria Paola | |
| Exploiting the Optical Tweezer technology to reveal thymidylate synthase interactions with its consensus mRNA | 1-gen-2023 | Malpezzi, Giulia; Viander, Xavier; Zaltron, Annamaria; Neri, Benedetta; Di Felice, Giulia; Tagliazucchi, Lorenzo; Aiello, Daniele; Moschella, MARIA GAETANA; Costi, Maria Paola; D'Arca, Domenico; Cecconi, Ciro | |
| EXPLOITING THE OPTICAL TWEEZER, A SINGLE MOLECULE TECHNOLOGY, TO REVEAL THYMIDYLATE SYNTHASE INTERACTIONS WITH ITS CONSENSUS mRNA | 1-gen-2023 | Malpezzi, Giulia; Viander, Xavier; Zaltron, Annamaria; Neri, Benedetta; Di Felice, Giulia; Tagliazucchi, Lorenzo; Aiello, Daniele; Moschella, Maria; Costi, Maria Paola; D’Arcae, Domenico; Cecconi, Ciro | |
| Exploring thymidylate synthase mRNA binding site 1 and human TS protein interaction with optical tweezers and bicistronic expression assay | 1-gen-2024 | Malpezzi, Giulia; Viander, Xavier; Zaltron, Annamaria; Tagliazucchi, Lorenzo; Aiello, Daniele; D’Arca, Domenico; Cecconi, Ciro; Costi, Maria Paola | |
| Expression, purification, and characterization of Transcriptional Enhancer Associated Domain (hTEAD4), a promising target for anticancer agents | 1-gen-2022 | Tagliazucchi, L; Rossi, Marianna; Pozzi, Cecilia; Lopresti, Ludovica; Aiello, D; Venturelli, A; Ponterini, G; Costi, Mp | |
| Intersite Communication in Dimeric Enzymes Highlighted by Structural and Thermodynamic Analysis of Didansyltyrosine Binding to Thymidylate Synthases | 1-gen-2024 | Costi, Maria Paola; Venturelli, Alberto; Guaitoli, Giambattista; Vanossi, Davide; Saitta, Francesca; Fessas, Dimitrios; Vitiello, Simone; Malpezzi, Giulia; Aiello, Daniele; Ferrari, Stefania; Tondi, Donatella; Ponterini, Glauco; Costi, Maria Paola | |
| Investigating the mechanism of action of the antiparasitic agent H80 through imaging techniques | 1-gen-2023 | Malpezzi, Giulia; Tagliazucchi, Lorenzo; Aiello, Daniele; Venturelli, Alberto; CORDEIRO DA SILVA, Anabela; Santarem, Nuno; Ponterini, Glauco; Costi, Maria Paola | |
| Lead optimization of human thymidylate synthase dimer disrupters: from computational studies to evaluation of their biological profiles | 1-gen-2023 | Aiello, Daniele; Malpezzi, Giulia; Tagliazucchi, Lorenzo; Moschella, MARIA GAETANA; Giulia, Saporito; Venturelli, Alberto; Gluaco, Ponterini; D'Arca, Domenico; Marverti, Gaetano; Federico, Falchi; Costi, Maria Paola | |
| Lead-optimization process and characterization of the dissociative effect applied to new dimer disrupters of human Thymidylate Synthase | 1-gen-2022 | Aiello, Daniele; Ascione, Cristian; Tagliazucchi, Lorenzo; Malpezzi, Giulia; Cassanelli, Valentina; Ponterini, Glauco; D'Arca, Domenico; Marverti, Gaetano; Moschella, MARIA GAETANA; Falchi, Federico; Venturelli, Alberto; Costi, Maria Paola | |
| One Health Approach in Drug Discovery for Leishmaniasis by Targeting Calpain cys-protease. | 1-gen-2024 | Aiello, Daniele; Tagliazucchi, Lorenzo; Malpezzi, Giulia; Mazzorana, Marco; Pozzi, Cecilia; Brancale, Andrea; Costi, Maria Paola | |
| Optimization of chemical-biological tools for characterizing the activity of dissociative inhibitor of human thymidylate synthase | 1-gen-2024 | Saporito, Giulia; Aiello, Daniele; Malpezzi, Giulia; Tagliazucchi, Lorenzo; Venturelli, Alberto; Falchi, Federico; Ponterini, Glauco; Costi, Maria Paola | |
| Preclinical investigation of H80 compared to miltefosine: imaging and proteomics for sustainable drug development | 1-gen-2024 | Malpezzi, Giulia; Tagliazucchi, Lorenzo; Aiello, Daniele; Venturelli, Alberto; Cordeiro-da-Silva, Anabela; Santarem, Nuno; Ponterini, Glauco; Costi, Maria Paola |