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Fanny Chereau, Yoann Madec, Caroline Sabin, Niels Obel, Ezequiel Ruiz-Mateos, Georgios Chrysos, Sarah Fidler, Clara Lehmann, Robert Zangerle, Linda Wittkop, Peter Reiss, Osamah Hamouda, Vicente Estrada Perez, Manuel Leal, Amanda Mocroft, Patricia Garcia De Olalla, Adriana Ammassari, Antonella D’Arminio Monforte, Cristina Mussini, Ferran Segura, Antonella Castagna, Matthias Cavassini, Sophie Grabar, Philippe Morlat, Stéphane De Wit, Olivier Lambotte, Laurence Meyer, The HIV Controllers Project Working Group for the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) in EuroCOORD
Impact of CD4 and CD8 dynamics and viral rebounds on loss of virological control in HIV controllers
www.plosone.org
www.plosone.org
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(01/01/1996)Tj
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q
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1 J
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11.9999 0 0 11.9999 200.0125 419.1307 cm
BT
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4.3275 0 Td
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1.8757 0 Td
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1.4514 0 Td
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1.9842 0 Td
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Q
q
1 j
1 J
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7.4999 0 0 6.6659 456.2078 341.5748 cm
BT
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1 TL
-0.0053 Tc
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ET
Q
q
1 j
1 J
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1 J
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7.4999 0 0 6.6659 262.9984 328.5921 cm
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1 TL
-0.0053 Tc
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(th)Tj
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Q
q
1 j
1 J
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Q
q
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1 J
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7.4999 0 0 6.6659 444.8125 328.5921 cm
BT
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1 TL
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(st)Tj
ET
Q
q
1 j
1 J
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1 TL
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Q
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1 j
1 J
0 w
7.4999 0 0 6.6659 212.2015 244.4598 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
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(10)Tj
ET
Q
q
1 j
1 J
0 w
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BT
/F6 1 Tf
1 TL
-0.004 Tc
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(copies/mL)Tj
4.405 0 Td
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2.2053 0 Td
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(VL)Tj
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Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 373.5496 244.4598 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
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(10)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 382.8472 246.1606 cm
BT
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1 TL
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(copies/mL,)Tj
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(100)Tj
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Q
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1 J
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7.4999 0 0 6.6659 274.7338 237.6 cm
BT
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1 TL
-0.0053 Tc
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(3)Tj
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Q
q
1 j
1 J
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(20)Tj
0 g
(].)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
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(to)Tj
1.0261 0 Td
(determine)Tj
-31.9575 -1.3039 Td
(their)Tj
2.109 0 Td
(HCV)Tj
2.3414 0 Td
(status)Tj
2.5002 0 Td
(in)Tj
1.0374 0 Td
(COHERE)Tj
4.1556 0 Td
(database.)Tj
3.8664 0 Td
(Among)Tj
3.2428 0 Td
(those)Tj
2.3414 0 Td
(with)Tj
1.9956 0 Td
(a)Tj
0.652 0 Td
(known)Tj
3.0047 0 Td
(HCV)Tj
2.3471 0 Td
(status,)Tj
2.7268 0 Td
(HIV-HCV)Tj
-32.3204 -1.2983 Td
(coinfection)Tj
4.7225 0 Td
(was)Tj
1.6951 0 Td
(identified)Tj
4.0592 0 Td
(in)Tj
1.0375 0 Td
(69.7%)Tj
2.6305 0 Td
(of)Tj
1.0148 0 Td
(HICs)Tj
2.3528 0 Td
(and)Tj
1.7291 0 Td
(59.5%)Tj
2.6305 0 Td
(of)Tj
1.0148 0 Td
(non-HICs)Tj
4.303 0 Td
(\(data)Tj
2.2564 0 Td
(not)Tj
1.5702 0 Td
(shown\).)Tj
-29.8201 -1.2982 Td
(Among)Tj
3.2484 0 Td
(the)Tj
1.4684 0 Td
(1067)Tj
2.1203 0 Td
(HICs,)Tj
2.5795 0 Td
(86)Tj
1.1735 0 Td
(experienced)Tj
5.0343 0 Td
(loss)Tj
1.6951 0 Td
(of)Tj
1.0148 0 Td
(virological)Tj
4.405 0 Td
(control,)Tj
3.3506 0 Td
(293)Tj
1.6441 0 Td
(initiated)Tj
3.5545 0 Td
(ART)Tj
2.1373 0 Td
(and)Tj
1.7291 0 Td
(13)Tj
-36.3512 -1.2983 Td
(died)Tj
1.9673 0 Td
(during)Tj
2.9253 0 Td
(virological)Tj
4.4107 0 Td
(control)Tj
3.1181 0 Td
(\(3)Tj
1.0375 0 Td
(from)Tj
2.2053 0 Td
(non-AIDS)Tj
4.4107 0 Td
(defining)Tj
3.5546 0 Td
(infections,)Tj
4.3823 0 Td
(2)Tj
0.6917 0 Td
(cardiovascular)Tj
6.0036 0 Td
(dis-)Tj
-34.7071 -1.3039 Td
(eases,)Tj
2.4492 0 Td
(1)Tj
0.6916 0 Td
(chronic)Tj
3.2882 0 Td
(hepatitis)Tj
3.617 0 Td
(C,)Tj
1.1055 0 Td
(1)Tj
0.6973 0 Td
(carcinoma,)Tj
4.6771 0 Td
(1)Tj
0.6917 0 Td
(mental)Tj
2.9933 0 Td
(disorder)Tj
3.5773 0 Td
(related)Tj
2.9424 0 Td
(to)Tj
1.0261 0 Td
(drug)Tj
2.1089 0 Td
(abuse)Tj
2.4774 0 Td
(and)Tj
1.7292 0 Td
(5)Tj
-34.0722 -1.2983 Td
(unknown/unreported)Tj
8.9235 0 Td
(causes)Tj
2.7552 0 Td
(of)Tj
1.0148 0 Td
(death\).)Tj
2.9934 0 Td
(The)Tj
1.7858 0 Td
(remaining)Tj
4.3653 0 Td
(675)Tj
1.6441 0 Td
(HICs)Tj
2.3527 0 Td
(maintained)Tj
4.7905 0 Td
(virological)Tj
4.405 0 Td
(con-)Tj
-35.0303 -1.2982 Td
(trol)Tj
1.6441 0 Td
(up)Tj
1.2643 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4683 0 Td
(end)Tj
1.7178 0 Td
(of)Tj
1.0148 0 Td
(follow-up)Tj
4.0932 0 Td
(and)Tj
1.7292 0 Td
(their)Tj
2.1089 0 Td
(follow-up)Tj
4.0932 0 Td
(was)Tj
1.7008 0 Td
(therefore)Tj
3.8551 0 Td
(right-censored.)Tj
-24.5195 -1.304 Td
(The)Tj
1.7858 0 Td
(probabilities)Tj
5.193 0 Td
(of)Tj
1.0148 0 Td
(loss)Tj
1.6951 0 Td
(of)Tj
1.0148 0 Td
(virological)Tj
4.4107 0 Td
(control)Tj
3.1181 0 Td
(2,)Tj
0.9241 0 Td
(6)Tj
0.6916 0 Td
(and)Tj
1.7348 0 Td
(10)Tj
1.1679 0 Td
(years)Tj
2.2677 0 Td
(after)Tj
2.0352 0 Td
(confirmation)Tj
5.4991 0 Td
(of)Tj
1.0148 0 Td
(HIC)Tj
-34.7638 -1.2982 Td
(status)Tj
2.5002 0 Td
(were)Tj
2.1203 0 Td
(2.0%,)Tj
2.3811 0 Td
(12.8%)Tj
2.6305 0 Td
(and)Tj
1.7291 0 Td
(19.0%,)Tj
2.8517 0 Td
(respectively)Tj
4.8869 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Fig)Tj
1.8198 0 Td
(1)Tj
0 g
(\).)Tj
1.2642 0 Td
(The)Tj
1.7802 0 Td
(corresponding)Tj
6.0603 0 Td
(probabilities)Tj
5.1931 0 Td
(for)Tj
-35.2174 -1.2983 Td
(ART)Tj
2.1374 0 Td
(initiation)Tj
3.9231 0 Td
(and)Tj
1.7291 0 Td
(death)Tj
2.4321 0 Td
(during)Tj
2.9253 0 Td
(virological)Tj
4.4107 0 Td
(control)Tj
3.1238 0 Td
(are)Tj
1.4456 0 Td
(illustrated)Tj
4.2236 0 Td
(in)Tj
0.83 0.64 0.02 0 k
1.0318 0 Td
(Fig)Tj
1.4854 0 Td
(1)Tj
0 g
(.)Tj
0.9183 0 Td
(Altogether,)Tj
4.6885 0 Td
(the)Tj
-34.4747 -1.3039 Td
(probabilities)Tj
5.1931 0 Td
(of)Tj
1.0148 0 Td
(maintaining)Tj
5.1193 0 Td
(HIC)Tj
1.9899 0 Td
(status)Tj
2.5002 0 Td
(2,)Tj
0.9184 0 Td
(6)Tj
0.6973 0 Td
(and)Tj
1.7291 0 Td
(10)Tj
1.1736 0 Td
(years)Tj
2.262 0 Td
(after)Tj
2.0353 0 Td
(confirmation)Tj
5.499 0 Td
(of)Tj
1.0148 0 Td
(HIC)Tj
1.9956 0 Td
(status)Tj
2.5002 0 Td
(were)Tj
-35.6426 -1.2983 Td
(78.0%)Tj
2.6306 0 Td
([75.180.7],)Tj
4.9436 0 Td
(48.4%)Tj
2.6305 0 Td
([44.152.6])Tj
4.7225 0 Td
(and)Tj
1.7291 0 Td
(29.2%)Tj
2.6306 0 Td
([23.634.9],)Tj
4.9492 0 Td
(respectively.)Tj
-23.0398 -1.2982 Td
(During)Tj
3.1407 0 Td
(virological)Tj
4.405 0 Td
(control,)Tj
3.3506 0 Td
(310)Tj
1.644 0 Td
(HICs)Tj
2.3528 0 Td
(\(29.1%\))Tj
3.3108 0 Td
(experienced)Tj
5.0343 0 Td
(viral)Tj
1.9956 0 Td
(rebounds,)Tj
4.2178 0 Td
(including)Tj
4.0422 0 Td
(167)Tj
-34.6901 -1.2983 Td
(\(15.7%\))Tj
3.3109 0 Td
(with)Tj
1.9956 0 Td
(transient)Tj
3.77 0 Td
(rebounds)Tj
3.9912 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Table)Tj
2.7836 0 Td
(2)Tj
0 g
(\).)Tj
1.2642 0 Td
(The)Tj
1.7802 0 Td
(median)Tj
3.2428 0 Td
(delay)Tj
2.3017 0 Td
(from)Tj
2.2053 0 Td
(the)Tj
1.4741 0 Td
(confirmation)Tj
5.499 0 Td
(of)Tj
1.0148 0 Td
(HIC)Tj
-34.6334 -1.3039 Td
(status)Tj
2.5002 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(first)Tj
1.8028 0 Td
(rebound)Tj
3.634 0 Td
(was)Tj
1.7008 0 Td
(1.2)Tj
1.3946 0 Td
(years)Tj
2.2677 0 Td
(in)Tj
1.0318 0 Td
(those)Tj
2.3414 0 Td
(who)Tj
1.9389 0 Td
(experienced)Tj
5.0343 0 Td
(rebounds.)Tj
4.2178 0 Td
(The)Tj
1.7802 0 Td
(median)Tj
-32.139 -1.2983 Td
(\(IQR\))Tj
2.6079 0 Td
(maximum)Tj
4.371 0 Td
(level)Tj
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(reached)Tj
3.3505 0 Td
(during)Tj
2.9253 0 Td
(viral)Tj
1.9956 0 Td
(rebound)Tj
3.6283 0 Td
(was)Tj
1.7008 0 Td
(1140)Tj
2.126 0 Td
(\(7101980\))Tj
4.7451 0 Td
(copies/ml.)Tj
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(During)Tj
3.1407 0 Td
(virological)Tj
4.405 0 Td
(control,)Tj
3.3506 0 Td
(4)Tj
0.6916 0 Td
(HICs)Tj
2.3528 0 Td
(had)Tj
1.7121 0 Td
(no)Tj
1.2756 0 Td
(CD4)Tj
2.0919 0 Td
(measurements)Tj
6.0321 0 Td
(and)Tj
1.7348 0 Td
(261)Tj
1.6441 0 Td
(HICs)Tj
2.3526 0 Td
(had)Tj
1.7065 0 Td
(no)Tj
1.2755 0 Td
(CD8)Tj
-34.9622 -1.304 Td
(measurements.)Tj
6.2532 0 Td
(In)Tj
1.1112 0 Td
(HICs)Tj
2.3527 0 Td
(with)Tj
1.9956 0 Td
(measurements,)Tj
6.2589 0 Td
(the)Tj
1.4683 0 Td
(median)Tj
3.2428 0 Td
(\(IQR\))Tj
2.6079 0 Td
(number)Tj
3.4186 0 Td
(of)Tj
1.0147 0 Td
(VL,)Tj
1.678 0 Td
(CD4)Tj
2.092 0 Td
(and)Tj
1.7291 0 Td
(CD8)Tj
-35.223 -1.2982 Td
(measurements)Tj
6.0321 0 Td
(during)Tj
2.9254 0 Td
(virological)Tj
4.4106 0 Td
(control)Tj
3.1238 0 Td
(were)Tj
2.1203 0 Td
(11)Tj
1.1735 0 Td
(\(816\),)Tj
3.0671 0 Td
(12)Tj
1.1735 0 Td
(\(817\))Tj
2.8403 0 Td
(and)Tj
1.7292 0 Td
(11)Tj
1.1734 0 Td
(\(716\),)Tj
ET
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q
0.45 0.36 0.35 0.01 k
1 j
1 J
0 w
36 703.8893 m
576 703.8893 l
576 703.3893 l
36 703.3893 l
f*
284.3612 703.3893 m
284.3612 690.8893 l
283.8611 690.8893 l
283.8611 703.3893 l
f*
283.8611 690.8893 m
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283.8611 691.3894 l
f*
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f*
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429.9304 691.3894 l
f*
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575.9997 691.3894 l
f*
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f*
283.8611 678.3894 m
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f*
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f*
429.9304 678.3894 m
284.3612 678.3894 l
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429.9304 678.8894 l
f*
575.9997 678.3894 m
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575.9997 678.8894 l
f*
284.3612 678.3894 m
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283.8611 665.8894 l
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f*
283.8611 665.8894 m
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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575.9997 653.8895 l
f*
284.3612 653.3895 m
284.3612 640.8896 l
283.8611 640.8896 l
283.8611 653.3895 l
f*
283.8611 640.8896 m
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283.8611 641.3896 l
f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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