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Thomas D. Brothers, Susan Kirkland, Olga Theou, Stefano Zona, Andrea Malagoli, Lindsay M. K. Wallace, Chiara Stentarelli, Cristina Mussini, Julian Falutz, Giovanni Guaraldi, Kenneth Rockwood
Predictors of transitions in frailty severity and mortality among people aging with HIV
www.plosone.org
www.plosone.org
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348.4389 204.8871 l
348.4389 219.3871 l
f*
348.4389 204.8871 m
199.9998 204.8871 l
199.9998 205.3871 l
348.4389 205.3871 l
f*
575.9997 204.8871 m
348.9389 204.8871 l
348.9389 205.3871 l
575.9997 205.3871 l
f*
348.9389 204.8871 m
348.9389 190.387 l
348.4389 190.387 l
348.4389 204.8871 l
f*
348.4389 190.387 m
199.9998 190.387 l
199.9998 190.887 l
348.4389 190.887 l
f*
575.9997 190.387 m
348.9389 190.387 l
348.9389 190.887 l
575.9997 190.887 l
f*
348.9389 190.387 m
348.9389 175.8869 l
348.4389 175.8869 l
348.4389 190.387 l
f*
348.4389 175.8869 m
199.9998 175.8869 l
199.9998 176.387 l
348.4389 176.387 l
f*
575.9997 175.8869 m
348.9389 175.8869 l
348.9389 176.387 l
575.9997 176.387 l
f*
348.9389 175.8869 m
348.9389 151.8868 l
348.4389 151.8868 l
348.4389 175.8869 l
f*
348.4389 151.8868 m
199.9998 151.8868 l
199.9998 152.3869 l
348.4389 152.3869 l
f*
575.9997 151.8868 m
348.9389 151.8868 l
348.9389 152.3869 l
575.9997 152.3869 l
f*
0.83 0.64 0.02 0 k
403.7102 488.8063 m
412.4976 488.8063 l
h
f*
404.674 375.8173 m
413.4614 375.8173 l
h
f*
526.9039 179.8299 m
535.6913 179.8299 l
h
f*
200.0126 138.7843 m
350.7591 138.7843 l
h
f*
0 g
1 j
1 J
7.9999 0 0 7.9999 200.0125 708.7181 cm
BT
/F2 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Table)Tj
2.7992 0 Td
(1.)Tj
1.2614 0 Td
(Health)Tj
3.2315 0 Td
(variables)Tj
4.4859 0 Td
(included)Tj
4.2945 0 Td
(in)Tj
1.0985 0 Td
(the)Tj
1.7008 0 Td
(frailty)Tj
2.8984 0 Td
(index)Tj
2.7992 0 Td
(and)Tj
1.9772 0 Td
(descriptions)Tj
6.0946 0 Td
(of)Tj
1.1551 0 Td
(health)Tj
3.1252 0 Td
(deficit)Tj
3.1252 0 Td
(criteria.)Tj
0 Tc
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(Variable)Tj
18.8647 0 Td
(Descriptio)Tj
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(n)Tj
0.8433 0 Td
(of)Tj
1.1764 0 Td
(health)Tj
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(deficit)Tj
/F0 1 Tf
-28.9207 -1.559 Td
(Chronic)Tj
3.6425 0 Td
(kidney)Tj
3.0969 0 Td
(disease)Tj
12.5009 0 Td
()Tj
0.7299 0 Td
(Two)Tj
2.1047 0 Td
(estimated)Tj
4.5426 0 Td
(glomerular)Tj
4.911 0 Td
(filtration)Tj
3.7135 0 Td
(rate)Tj
1.9417 0 Td
(measurem)Tj
4.6914 0 Td
(ents)Tj
/F5 1 Tf
2.1118 0 Td
[( )]TJ
/F0 1 Tf
0.8079 0 Td
(60)Tj
-24.8246 -1.1906 Td
(mL/min/)Tj
3.5362 0 Td
(1)Tj
/F11 1 Tf
()Tj
/F0 1 Tf
(73m)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 410.1165 675.4393 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 200.0125 657.411 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(NAFLD)Tj
19.2403 0 Td
()Tj
0.7299 0 Td
(Liver/spl)Tj
3.6921 0 Td
(een)Tj
1.8851 0 Td
(ratio)Tj
/F5 1 Tf
2.1614 0 Td
[( )]TJ
/F0 1 Tf
0.8079 0 Td
(1.1)Tj
-28.5167 -1.8141 Td
(Osteopo)Tj
3.7559 0 Td
(rosis)Tj
15.4844 0 Td
()Tj
0.7299 0 Td
(Dual-energ)Tj
4.8969 0 Td
(y)Tj
0.7299 0 Td
(x-ray)Tj
2.4449 0 Td
(absorptiom)Tj
4.9111 0 Td
(etry)Tj
1.8921 0 Td
(\(DEXA\))Tj
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(T-)Tj
1.1764 0 Td
(or)Tj
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(Z-score)Tj
/F5 1 Tf
3.6071 0 Td
[( )]TJ
/F0 1 Tf
-24.371 -1.1906 Td
(-2.5)Tj
1.9417 0 Td
(or)Tj
1.1126 0 Td
(fragility)Tj
3.3733 0 Td
(fracture)Tj
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(Menopa)Tj
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(use)Tj
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(or)Tj
1.1126 0 Td
(male)Tj
2.3811 0 Td
(hypogonadis)Tj
5.6197 0 Td
(m)Tj
4.7198 0 Td
()Tj
0.7299 0 Td
(If)Tj
0.7866 0 Td
(female:)Tj
3.4937 0 Td
(FSH)Tj
/F5 1 Tf
[( !)]TJ
/F0 1 Tf
(30)Tj
3.9048 0 Td
(IU/L)Tj
2.0551 0 Td
(&)Tj
0.9 0 Td
(LH)Tj
/F5 1 Tf
[( )]TJ
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(30)Tj
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(IU/L)Tj
2.0622 0 Td
(and/or)Tj
3.0402 0 Td
(absence)Tj
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(of)Tj
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(menstrua)Tj
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(tion)Tj
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1.8354 0 Td
[( !)]TJ
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(1)Tj
1.3607 0 Td
(year;)Tj
-8.0646 -1.4386 Td
()Tj
0.7299 0 Td
(If)Tj
0.7866 0 Td
(male:)Tj
2.6646 0 Td
(testosteron)Tj
4.9181 0 Td
(e)Tj
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[( )]TJ
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(300)Tj
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(ng/dL)Tj
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2.2606 0 Td
(or)Tj
1.1126 0 Td
(low)Tj
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(body)Tj
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(mass)Tj
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(index)Tj
9.1631 0 Td
()Tj
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0.7299 0 Td
[( )]TJ
/F0 1 Tf
(18)Tj
1.9134 0 Td
(or)Tj
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1.1126 0 Td
[( !)]TJ
/F0 1 Tf
(25)Tj
1.9063 0 Td
(kg/m)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 416.5228 586.9417 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 200.0125 568.9133 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(High)Tj
2.2606 0 Td
(waist)Tj
2.4945 0 Td
(circumfere)Tj
4.6418 0 Td
(nce)Tj
9.8434 0 Td
()Tj
0.7299 0 Td
(If)Tj
0.7866 0 Td
(female:)Tj
/F5 1 Tf
3.4937 0 Td
[( !)]TJ
/F0 1 Tf
(88)Tj
1.9134 0 Td
(cm;)Tj
-6.9236 -1.4385 Td
()Tj
0.7299 0 Td
(If)Tj
0.7866 0 Td
(male:)Tj
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2.6646 0 Td
[( !)]TJ
/F0 1 Tf
(102)Tj
2.4591 0 Td
(cm)Tj
-25.8805 -1.8142 Td
(High)Tj
2.2606 0 Td
(visceral)Tj
3.6 0 Td
(adipos)Tj
2.9126 0 Td
(e)Tj
0.7796 0 Td
(tissue)Tj
2.8276 0 Td
(\(VAT\))Tj
6.8599 0 Td
()Tj
0.7299 0 Td
(VAT)Tj
/F5 1 Tf
[( !)]TJ
/F0 1 Tf
(130)Tj
4.4008 0 Td
(cm)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 405.6377 546.4629 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 410.7968 542.8913 cm
BT
/F0 1 Tf
1 TL
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(or)Tj
1.1126 0 Td
(VAT/TA)Tj
3.4937 0 Td
(T)Tj
0.8433 0 Td
(ratio)Tj
/F5 1 Tf
2.1614 0 Td
[( !)]TJ
/F0 1 Tf
(0.5)Tj
-33.9592 -1.8141 Td
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3.6922 0 Td
(nia)Tj
1.5519 0 Td
(or)Tj
1.1127 0 Td
(presarcope)Tj
4.9606 0 Td
(nia)Tj
7.9229 0 Td
()Tj
0.7299 0 Td
(Fat-free)Tj
3.7205 0 Td
(mass)Tj
2.6079 0 Td
(index)Tj
/F5 1 Tf
2.5937 0 Td
[( )]TJ
/F0 1 Tf
0.8149 0 Td
(-1)Tj
1.1126 0 Td
(SD)Tj
-30.8198 -1.8142 Td
(Unemploy)Tj
4.4646 0 Td
(ment)Tj
14.7757 0 Td
()Tj
0.7299 0 Td
(Self-repo)Tj
4.0253 0 Td
(rt)Tj
-23.9955 -1.8071 Td
(Insulin)Tj
3.0969 0 Td
(resistance)Tj
4.7551 0 Td
(\(HOMA\))Tj
11.3883 0 Td
()Tj
0.7299 0 Td
(Homeos)Tj
3.6922 0 Td
(tasis)Tj
2.2819 0 Td
(Model)Tj
2.9267 0 Td
(Assessmen)Tj
5.1378 0 Td
(tInsulin)Tj
3.9261 0 Td
(Resistance)Tj
-17.9647 -1.1906 Td
(\(HOMA-I)Tj
3.9331 0 Td
(R\))Tj
1.2827 0 Td
([)Tj
0.83 0.64 0.02 0 k
(51)Tj
0 g
(])Tj
/F5 1 Tf
1.8921 0 Td
[( !)]TJ
/F0 1 Tf
0.8079 0 Td
(2.8)Tj
-27.886 -1.8142 Td
(High)Tj
2.2607 0 Td
(total)Tj
2.1118 0 Td
(cholestero)Tj
4.578 0 Td
(l)Tj
10.2898 0 Td
()Tj
/F5 1 Tf
0.7299 0 Td
[( !)]TJ
/F0 1 Tf
0.8079 0 Td
(200)Tj
1.8851 0 Td
(mg/dL)Tj
-22.6632 -1.8071 Td
(High)Tj
2.2607 0 Td
(low)Tj
1.7149 0 Td
(density)Tj
3.3804 0 Td
(lipoprot)Tj
3.2457 0 Td
(ein)Tj
8.6386 0 Td
()Tj
/F5 1 Tf
0.7299 0 Td
[( !)]TJ
/F0 1 Tf
(100)Tj
2.4591 0 Td
(mg/dL)Tj
-22.4293 -1.8142 Td
(Low)Tj
2.0481 0 Td
(high)Tj
2.0976 0 Td
(density)Tj
3.3733 0 Td
(lipoprotein)Tj
11.7213 0 Td
()Tj
/F5 1 Tf
0.7299 0 Td
[( )]TJ
/F0 1 Tf
0.8079 0 Td
(40)Tj
1.3323 0 Td
(mg/dL)Tj
-22.1104 -1.8141 Td
(High)Tj
2.2607 0 Td
(triglyceride)Tj
4.7976 0 Td
(s)Tj
12.182 0 Td
()Tj
/F5 1 Tf
0.7299 0 Td
[( !)]TJ
/F0 1 Tf
(150)Tj
2.4591 0 Td
(mg/dL)Tj
-22.4293 -1.8142 Td
(Abnorma)Tj
4.0252 0 Td
(l)Tj
0.4536 0 Td
(leukocy)Tj
3.3591 0 Td
(te)Tj
1.063 0 Td
(counts)Tj
10.3394 0 Td
()Tj
/F5 1 Tf
0.7299 0 Td
[( )]TJ
/F0 1 Tf
0.8079 0 Td
(4000)Tj
2.4308 0 Td
(cells/)Tj
/F5 1 Tf
[()]TJ
/F0 1 Tf
(L)Tj
-23.2089 -1.8142 Td
(Anemia)Tj
19.2403 0 Td
()Tj
0.7299 0 Td
(If)Tj
0.7867 0 Td
(female,)Tj
/F5 1 Tf
3.4937 0 Td
[( )]TJ
/F0 1 Tf
0.8079 0 Td
(10)Tj
1.3322 0 Td
(grams/dL;)Tj
-7.1504 -1.4315 Td
()Tj
0.7299 0 Td
(If)Tj
0.7867 0 Td
(male,)Tj
/F5 1 Tf
2.6646 0 Td
[( )]TJ
/F0 1 Tf
0.8078 0 Td
(12)Tj
1.3323 0 Td
(grams/dL.)Tj
-25.5616 -1.8142 Td
(Cirrhosis)Tj
19.2403 0 Td
()Tj
0.7299 0 Td
(FIB-4)Tj
2.6717 0 Td
(score)Tj
2.6575 0 Td
([)Tj
0.83 0.64 0.02 0 k
(52)Tj
0 g
(])Tj
/F5 1 Tf
1.8921 0 Td
[( !)]TJ
/F0 1 Tf
0.8078 0 Td
(3.25)Tj
-27.9993 -1.8142 Td
(Abnorma)Tj
4.0252 0 Td
(l)Tj
0.4536 0 Td
(potassiu)Tj
3.6921 0 Td
(m)Tj
11.0694 0 Td
()Tj
/F5 1 Tf
0.7299 0 Td
[( )]TJ
/F0 1 Tf
0.8079 0 Td
(3.5)Tj
1.6158 0 Td
(or)Tj
/F5 1 Tf
1.1126 0 Td
[( !)]TJ
/F0 1 Tf
0.8079 0 Td
(5.3)Tj
1.6157 0 Td
(mEq/L)Tj
-25.9301 -1.8142 Td
(Abnorma)Tj
4.0252 0 Td
(l)Tj
0.4536 0 Td
(phosph)Tj
3.2457 0 Td
(orus)Tj
11.5158 0 Td
()Tj
/F5 1 Tf
0.7299 0 Td
[( )]TJ
/F0 1 Tf
0.8079 0 Td
(2.5)Tj
1.6158 0 Td
(or)Tj
/F5 1 Tf
1.1126 0 Td
[( !)]TJ
/F0 1 Tf
0.8079 0 Td
(5.1)Tj
1.6157 0 Td
(mg/dL)Tj
-25.9301 -1.8071 Td
(Abnorma)Tj
4.0252 0 Td
(l)Tj
0.4536 0 Td
(thyroid)Tj
3.2102 0 Td
(stimula)Tj
3.1394 0 Td
(ting)Tj
1.8355 0 Td
(hormon)Tj
3.3591 0 Td
(e)Tj
3.2173 0 Td
()Tj
/F5 1 Tf
0.7299 0 Td
[( )]TJ
/F0 1 Tf
0.8079 0 Td
(0.27)Tj
2.1615 0 Td
(or)Tj
/F5 1 Tf
1.1126 0 Td
[( !)]TJ
/F0 1 Tf
0.8149 0 Td
(4.2)Tj
1.6086 0 Td
(mIU/L)Tj
-26.4757 -1.8142 Td
(Proteinu)Tj
3.6922 0 Td
(ria)Tj
1.3323 0 Td
(or)Tj
1.1126 0 Td
(albuminuria)Tj
13.1032 0 Td
()Tj
/F5 1 Tf
0.7299 0 Td
[( !)]TJ
/F0 1 Tf
0.8079 0 Td
(5)Tj
0.7796 0 Td
(mg/mmol)Tj
-21.5577 -1.8142 Td
(Elevated)Tj
4.089 0 Td
(aspartate)Tj
4.3725 0 Td
(transamina)Tj
4.9111 0 Td
(se)Tj
1.2826 0 Td
(\(AST\))Tj
4.5851 0 Td
()Tj
/F5 1 Tf
0.7299 0 Td
[( !)]TJ
/F0 1 Tf
0.8079 0 Td
(31)Tj
1.3323 0 Td
(U/L)Tj
-22.1104 -1.8142 Td
(Elevated)Tj
4.089 0 Td
(alanine)Tj
3.4229 0 Td
(transami)Tj
3.8055 0 Td
(nase)Tj
2.3811 0 Td
(\(ALT\))Tj
5.5418 0 Td
()Tj
/F5 1 Tf
0.7299 0 Td
[( !)]TJ
/F0 1 Tf
0.8079 0 Td
(31)Tj
1.3323 0 Td
(U/L)Tj
-22.1104 -1.8071 Td
(Elevated)Tj
4.089 0 Td
(gamma-glut)Tj
5.2442 0 Td
(amyl)Tj
-9.3332 -1.1905 Td
(transphos)Tj
4.3583 0 Td
(phatase)Tj
3.763 0 Td
(\(GGT\))Tj
11.119 1.1905 Td
()Tj
/F5 1 Tf
0.7299 0 Td
[( !)]TJ
/F0 1 Tf
0.8079 0 Td
(55)Tj
1.3323 0 Td
(U/L)Tj
-22.1104 -2.7567 Td
(Thromb)Tj
3.4229 0 Td
(ocytopenia)Tj
15.8174 0 Td
()Tj
/F5 1 Tf
0.7299 0 Td
[( )]TJ
/F0 1 Tf
0.8079 0 Td
(150)Tj
1.8851 0 Td
(billion/L)Tj
-22.6632 -1.8071 Td
(Elevated)Tj
4.089 0 Td
(total)Tj
2.1118 0 Td
(bilirubin)Tj
13.0395 0 Td
()Tj
/F5 1 Tf
0.7299 0 Td
[( !)]TJ
/F0 1 Tf
0.8079 0 Td
(1)Tj
/F11 1 Tf
()Tj
/F0 1 Tf
(10)Tj
2.1544 0 Td
(mg/dL)Tj
-22.9325 -1.8142 Td
(Abnorma)Tj
4.0252 0 Td
(l)Tj
0.4536 0 Td
(parathyroi)Tj
4.4079 0 Td
(d)Tj
0.7795 0 Td
(hormone)Tj
9.5741 0 Td
()Tj
/F5 1 Tf
0.7299 0 Td
[( !)]TJ
/F0 1 Tf
0.8079 0 Td
(60)Tj
1.3323 0 Td
(pg/mL)Tj
-22.1104 -1.8141 Td
(Elevated)Tj
4.089 0 Td
(C-reactive)Tj
4.7623 0 Td
(protein)Tj
10.389 0 Td
()Tj
/F5 1 Tf
0.7299 0 Td
[( !)]TJ
/F0 1 Tf
0.8079 0 Td
(0.7)Tj
1.6158 0 Td
(mg/L)Tj
-22.3939 -1.8142 Td
(Vitamin)Tj
3.5433 0 Td
(D)Tj
0.9426 0 Td
(deficiency)Tj
14.7544 0 Td
()Tj
/F5 1 Tf
0.7299 0 Td
[( )]TJ
/F0 1 Tf
0.8079 0 Td
(30)Tj
1.3323 0 Td
(ng/mL)Tj
-22.1104 -1.8071 Td
(Lipoatro)Tj
3.5788 0 Td
(phy)Tj
15.6615 0 Td
()Tj
0.7299 0 Td
(Multicen)Tj
3.6922 0 Td
(ter)Tj
1.3961 0 Td
(AIDS)Tj
2.5582 0 Td
(Cohort)Tj
3.2102 0 Td
(Study)Tj
2.7709 0 Td
(\(MACS\))Tj
3.7701 0 Td
(criteria)Tj
3.2103 0 Td
([)Tj
0.83 0.64 0.02 0 k
(53)Tj
0 g
(])Tj
-40.5782 -1.8142 Td
(Lipohypert)Tj
4.6276 0 Td
(rophy)Tj
14.6127 0 Td
()Tj
0.7299 0 Td
(MACS)Tj
3.104 0 Td
(criteria)Tj
0.83 0.64 0.02 0 k
/F8 1 Tf
-0.025 Tc
-23.0742 -3.3166 Td
(https://d)Tj
3.0827 0 Td
(oi.org/10.1371/j)Tj
5.9174 0 Td
(ournal.pon)Tj
3.9827 0 Td
(e.0185352.t00)Tj
5.3859 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 447.9874 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Predict)Tj
3.0543 0 Td
(ors)Tj
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