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Alba Murgia, Elena Veronesi, Olivia Candini, Anna Caselli, Naomi D’souza, Valeria Rasini, Andrea Giorgini, Fabio Catani, Lorenzo Iughetti, Massimo Dominici, Jorge S. Burns
Potency Biomarker Signature Genes from Multiparametric Osteogenesis Assays: Will cGMP Human Bone Marrow Mesenchymal Stromal Cells Make Bone?
www.plosone.org
www.plosone.org
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f*
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429.3014 677.8894 m
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484.4049 677.8894 m
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f*
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f*
226.4984 652.8895 m
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f*
277.1991 652.8895 m
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f*
327.8999 652.8895 m
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f*
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f*
226.4984 627.8896 m
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226.4984 615.3897 l
f*
277.1991 627.8896 m
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f*
327.8999 627.8896 m
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484.4049 627.8896 m
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327.8999 690.3893 m
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226.4984 677.8894 m
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277.1991 690.3893 m
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f*
277.1991 677.8894 m
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327.8999 690.3893 m
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327.8999 677.8894 m
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378.6007 690.3893 m
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378.6007 677.8894 m
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429.3014 677.8894 m
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484.4049 690.3893 m
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484.4049 677.8894 m
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226.4984 665.3894 m
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f*
277.1991 677.8894 m
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f*
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f*
327.8999 665.3894 m
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378.6007 677.8894 m
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429.3014 677.8894 m
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484.4049 677.8894 m
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484.4049 665.3894 m
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82.2883 652.8895 m
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f*
135.9794 665.3894 m
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135.9794 652.8895 m
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226.4984 652.8895 m
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225.9984 653.3895 l
f*
277.1991 665.3894 m
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f*
277.1991 652.8895 m
226.4984 652.8895 l
226.4984 653.3895 l
276.6991 653.3895 l
f*
327.8999 665.3894 m
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327.3999 653.3895 l
327.3999 665.3894 l
f*
327.8999 652.8895 m
277.1991 652.8895 l
277.1991 653.3895 l
327.3999 653.3895 l
f*
378.6007 665.3894 m
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f*
378.6007 652.8895 m
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f*
429.3014 665.3894 m
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f*
429.3014 652.8895 m
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f*
484.4049 665.3894 m
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f*
484.4049 652.8895 m
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f*
575.9994 652.8895 m
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82.2883 652.8895 m
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f*
135.9794 652.8895 m
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f*
135.9794 640.3895 m
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f*
176.7946 652.8895 m
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f*
176.7946 640.3895 m
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f*
226.4984 652.8895 m
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f*
226.4984 640.3895 m
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225.9984 640.8896 l
f*
277.1991 652.8895 m
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f*
277.1991 640.3895 m
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f*
327.8999 652.8895 m
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327.3999 640.8896 l
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f*
327.8999 640.3895 m
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327.3999 640.8896 l
f*
378.6007 652.8895 m
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378.1006 652.8895 l
f*
378.6007 640.3895 m
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f*
429.3014 652.8895 m
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f*
429.3014 640.3895 m
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f*
484.4049 652.8895 m
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f*
484.4049 640.3895 m
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f*
575.9994 640.3895 m
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f*
82.2883 640.3895 m
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f*
82.2883 627.8896 m
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f*
135.9794 640.3895 m
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135.4793 628.3896 l
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f*
135.9794 627.8896 m
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f*
176.7946 640.3895 m
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f*
176.7946 627.8896 m
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f*
226.4984 640.3895 m
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225.9984 628.3896 l
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f*
226.4984 627.8896 m
176.7946 627.8896 l
176.7946 628.3896 l
225.9984 628.3896 l
f*
277.1991 640.3895 m
277.1991 627.8896 l
276.6991 628.3896 l
276.6991 640.3895 l
f*
277.1991 627.8896 m
226.4984 627.8896 l
226.4984 628.3896 l
276.6991 628.3896 l
f*
327.8999 640.3895 m
327.8999 627.8896 l
327.3999 628.3896 l
327.3999 640.3895 l
f*
327.8999 627.8896 m
277.1991 627.8896 l
277.1991 628.3896 l
327.3999 628.3896 l
f*
378.6007 640.3895 m
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378.1006 628.3896 l
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f*
378.6007 627.8896 m
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378.1006 628.3896 l
f*
429.3014 640.3895 m
429.3014 627.8896 l
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f*
429.3014 627.8896 m
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f*
484.4049 640.3895 m
484.4049 627.8896 l
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f*
484.4049 627.8896 m
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f*
575.9994 627.8896 m
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82.2883 627.8896 m
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f*
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176.7946 615.3897 m
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226.4984 627.8896 m
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f*
226.4984 615.3897 m
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225.9984 615.8897 l
f*
277.1991 627.8896 m
277.1991 615.3897 l
276.6991 615.8897 l
276.6991 627.8896 l
f*
277.1991 615.3897 m
226.4984 615.3897 l
226.4984 615.8897 l
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f*
327.8999 627.8896 m
327.8999 615.3897 l
327.3999 615.8897 l
327.3999 627.8896 l
f*
327.8999 615.3897 m
277.1991 615.3897 l
277.1991 615.8897 l
327.3999 615.8897 l
f*
378.6007 627.8896 m
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378.1006 615.8897 l
378.1006 627.8896 l
f*
378.6007 615.3897 m
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f*
429.3014 627.8896 m
429.3014 615.3897 l
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428.8014 627.8896 l
f*
429.3014 615.3897 m
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428.8014 615.8897 l
f*
484.4049 627.8896 m
484.4049 615.3897 l
483.9049 615.8897 l
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f*
484.4049 615.3897 m
429.3014 615.3897 l
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f*
575.9994 615.3897 m
484.4049 615.3897 l
484.4049 615.8897 l
575.9994 615.8897 l
f*
575.9994 569.6396 m
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36 570.1397 l
575.9994 570.1397 l
f*
0 g
7.9999 0 0 7.9999 36 708.7181 cm
BT
/F2 1 Tf
1 TL
0 0 Td
(Table)Tj
2.8275 0 Td
(1.)Tj
1.2685 0 Td
(Characte)Tj
4.245 0 Td
(risation)Tj
3.8268 0 Td
(of)Tj
1.1622 0 Td
(donor-speci)Tj
5.7118 0 Td
(fic)Tj
1.3819 0 Td
(cGMP-hBM-)Tj
5.6481 0 Td
(MSC)Tj
2.4378 0 Td
(populat)Tj
3.6071 0 Td
(ion.)Tj
-30.912 -1.8567 Td
(Donor)Tj
6.1583 0 Td
(Gender)Tj
6.7111 0 Td
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[(9)17( )23()-3()12()-5()13()1()7()1( )]TJ
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[()2()-1()-1()11()13()1()1( )8()]TJ
-33.5336 -1.2982 Td
[()6()]TJ
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[()-4()4()]TJ
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[()3()8( )19(\r)1(\n)-1()2()-6()10(\r)1()13()1(R)]TJ
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[()1( )8()5()-5()-10(\r)2()-6()-5()2()11( )8()]TJ
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[(.)17()1()7()5()5()-5()8( )4()]TJ
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[()-1()11()19()6()2()1()4()1( )19()-6()8()-29()]TJ
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[(3)9(8)37($)]TJ
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[()1()1()]TJ
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[(\n)-11()13()11()]TJ
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[()]TJ
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[(;8)37($)]TJ
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[()13()-9()8()1()-10($)3()2()]TJ
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[(-)-4()12()]TJ
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[(15H)]TJ
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[(*)]TJ
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[()2()1( )8()-6()2()]TJ
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[(3)9(8)37($)]TJ
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[( )10(\r)-2()8( )19()-5()1(\n)-11()2()-6()]TJ
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[()15()]TJ
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[()5()-9()-6()-6()-5()13()11()6()4()11()6()11()4()1()6()1()]TJ
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[()-19()-6()6(-)-4()3()8( )]TJ
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[(3)10(B)]TJ
ET
Q
q
1 j
1 J
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BT
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1 TL
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Q
q
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BT
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[(\);)]TJ
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[(S)-4(\r)-2()8( )19()-5()12()-6()18()-5()7()8()]TJ
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[($)41()11()6()1()2()-6()]TJ
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[()8()2()1()-1()1()5()6()1()8()]TJ
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[()14()6()1(=)1( )4(F)]TJ
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[(;)-3()-5()-4()]TJ
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[(+)15()1()4()]TJ
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[(\);)]TJ
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[()16()1()5()6()1()]TJ
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[()-4()4()]TJ
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[(.)20()1()5()]TJ
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[()17(T)4(;)]TJ
ET
Q
q
1 j
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7.4999 0 0 6.6659 347.5842 429.9023 cm
BT
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ET
Q
q
1 j
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BT
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[()5(')]TJ
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[(+)1()4()]TJ
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[( )10(\r)-2()8( )19()-5()1(\n)-11()2()-3()18()-5()2()11( )]TJ
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[()2(')11()13()2()5()2()2()11( )]TJ
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[()-6()8()8()7()1()]TJ
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[()1( )]TJ
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[()-7()1()-5()8()18()6()]TJ
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[(.)20()11()-29()1()8()13()]TJ
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[(\r)3()2()1( )8()]TJ
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[(93)6(+)]TJ
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[(\))7()-4()1()4()1(S)-4(\r)2()2()5()]TJ
ET
Q
q
1 j
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7.4999 0 0 6.6659 432.907 403.937 cm
BT
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ET
Q
q
1 j
1 J
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BT
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[()]TJ
0.83 0.64 0.02 0 k
[()19()10()10(QEE)1(\r)6()2()12()6()1( )3()-1()11(E)]TJ
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[(\))7()-4()1()4()1(S)-4(\r)2()2()5(E:)25()11()4(E9)17( )4()2()2(')]TJ
0 g
[()]TJ
11.1117 0 Td
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[()-4()4()-9()]TJ
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[()5()-5()8( )2( )4()-6()]TJ
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[()8( )]TJ
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[()1( )19()-5()13()11( )]TJ
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[()-9()]TJ
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[(\n)8()11()]TJ
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[(;8)37($)]TJ
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[()18()-4()4()1()]TJ
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[()-4()3()8( )]TJ
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[()7()1( )4()11()2()2()]TJ
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[(+)1()4()]TJ
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[()13()5()-2()18()-5()7()8()]TJ
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[()2(')11()13()2()5()2()2()11( )]TJ
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-34.0891 -1.3039 Td
[(,)-2()-6()]TJ
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[()1( )4()2()1()7()1( )4()11(\r)3()]TJ
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[(M)2()-6()-5()1( )]TJ
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[()]TJ
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[()35()]TJ
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[()]TJ
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[(")]TJ
ET
Q
q
1 j
1 J
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7.4999 0 0 6.6659 481.7196 364.9322 cm
BT
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( )Tj
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[()16()]TJ
ET
Q
q
1 j
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BT
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[()]TJ
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[(")]TJ
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[()]TJ
ET
Q
q
1 j
1 J
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11.9999 0 0 11.9999 200.0125 308.0125 cm
BT
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1 TL
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(In-vivo)Tj
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(\(BF\))Tj
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ET
Q
q
1 j
1 J
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10 0 0 10 200.0125 291.0047 cm
BT
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2.2847 0 Td
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[(;)-3()-1()-6()-5()2()]TJ
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2.8063 0 Td
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2.8403 0 Td
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4.4617 0 Td
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2.1826 0 Td
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-33.5449 -1.2982 Td
[()-9()11()6()1( )19()-5()-2()-4()]TJ
3.753 0 Td
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7.5175 0 Td
[(\n)-11()13()11()]TJ
2.194 0 Td
[()-5()2()6()]TJ
2.0239 0 Td
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2.6475 0 Td
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1.7008 0 Td
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2.5455 0 Td
[(\r)3()2()1( )8()]TJ
2.3698 0 Td
[(\n)8()11(\r)1()]TJ
1.8935 0 Td
[()1()19()6()-2()8( )19()-6()18()-5()2()11( )]TJ
5.3914 0 Td
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-34.52 -1.3039 Td
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2.8573 0 Td
[()-9()1()-2()8()-6()1( )]TJ
3.4922 0 Td
[()-2()8()]TJ
1.7008 0 Td
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1.491 0 Td
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ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 399.4015 269.4614 cm
BT
/F7 1 Tf
1 TL
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[()-7()2(EP)]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 418.1669 264.9826 cm
BT
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1 TL
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2.347 0 Td
[(\))7()13()-9()-3()2()11(\r)3()5()7()]TJ
4.3824 0 Td
[()2()2()-7()-4()5()-9()-6()]TJ
4.0025 0 Td
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-32.5471 -1.2982 Td
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2.0976 0 Td
[()4()-9()1()1(\n)-11()2()-6()]TJ
3.804 0 Td
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1.0262 0 Td
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3.8154 0 Td
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1.4683 0 Td
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2.2564 0 Td
[()-1()5()-5(E)-7()-3()8(\n)-11(\n)8()6()2()]TJ
4.9549 0 Td
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3.9288 0 Td
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3.0614 0 Td
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2.0523 0 Td
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[()8( )2()1()3()-4()3()]TJ
3.3278 0 Td
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2.092 0 Td
[()8( )3()2()2()5()-4()4()1()-5(,)-2()-6()]TJ
5.5898 0 Td
[()-3()12()-4()]TJ
1.9956 0 Td
[(%/I)]TJ
2.1487 0 Td
[()3()-7()11(\n)-17()12(\r)2()11()8( )4()]TJ
4.6714 0 Td
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1.7235 0 Td
[()-4()4()]TJ
1.4682 0 Td
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2.6589 0 Td
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1.7008 0 Td
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2.948 0 Td
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1.7234 0 Td
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-33.9303 -1.3039 Td
[(9)17( )4()3()2()2()11( )8()]TJ
3.804 0 Td
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()Tj
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4.4277 0 Td
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2.5681 0 Td
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1.7178 0 Td
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2.4321 0 Td
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2.6589 0 Td
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3.1294 0 Td
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1.4684 0 Td
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2.0693 0 Td
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2.0239 0 Td
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3.0557 0 Td
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2.4208 0 Td
[()1()3()5()-7()-6()-6()-5()2()11( )]TJ
4.1669 0 Td
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1.7008 0 Td
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2.0466 0 Td
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1.0261 0 Td
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2.1883 0 Td
[()]TJ
0.6577 0 Td
[(%)]TJ
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