The family of the mammalian small heat-shock proteins consists of 10 members (sHSPs/HSPBs: HSPB1-HSPB10) that all share a highly conserved C-terminal alpha-crystallin domain, important for the modulation of both their structural and functional properties. HSPB proteins are biochemically classified as molecular chaperones and participate in protein quality control, preventing the aggregation of unfolded or misfolded proteins and/or assisting in their degradation. Thus, several members of the HSPB family have been suggested to be protective in a number of neurodegenerative and neuromuscular diseases that are characterized by protein misfolding. However, the pro-refolding, anti-aggregation or pro-degradative properties of the various members of the HSPB family differ largely, thereby influencing their efficacy and protective functions. Such diversity depends on several factors, including biochemical and physical properties of the unfolded/misfolded client, the expression levels and the subcellular localization of both the chaperone and the client proteins. Furthermore, although some HSPB members are inefficient at inhibiting protein aggregation, they can still exert neuroprotective effects by other, as yet unidentified, manners; e.g. by maintaining the proper cellular redox state or/and by preventing the activation of the apoptotic cascade. Here, we will focus our attention on how the differences in the activities of the HSPB proteins can influence neurodegenerative and neuromuscular disorders characterized by accumulation of aggregate-prone proteins. Understanding their mechanism of action may allow us to target a specific member in a specific cell type/disease for therapeutic purposes.

Different anti-aggregation and pro-degradative functions of the members of the mammalian sHSP family in neurological disorders / Carra, Serena; Rusmini, P; Crippa, V; Giorgetti, E; Boncoraglio, A; Cristofani, R; Naujock, M; Meister, M; Minoia, M; Kampinga, Hh; Poletti, A.. - In: PHILOSOPHICAL TRANSACTIONS - ROYAL SOCIETY. BIOLOGICAL SCIENCES. - ISSN 0962-8436. - ELETTRONICO. - 368:(2013), pp. 1-13. [10.1098/rstb.2011.0409]

Different anti-aggregation and pro-degradative functions of the members of the mammalian sHSP family in neurological disorders.

CARRA, Serena;
2013

Abstract

The family of the mammalian small heat-shock proteins consists of 10 members (sHSPs/HSPBs: HSPB1-HSPB10) that all share a highly conserved C-terminal alpha-crystallin domain, important for the modulation of both their structural and functional properties. HSPB proteins are biochemically classified as molecular chaperones and participate in protein quality control, preventing the aggregation of unfolded or misfolded proteins and/or assisting in their degradation. Thus, several members of the HSPB family have been suggested to be protective in a number of neurodegenerative and neuromuscular diseases that are characterized by protein misfolding. However, the pro-refolding, anti-aggregation or pro-degradative properties of the various members of the HSPB family differ largely, thereby influencing their efficacy and protective functions. Such diversity depends on several factors, including biochemical and physical properties of the unfolded/misfolded client, the expression levels and the subcellular localization of both the chaperone and the client proteins. Furthermore, although some HSPB members are inefficient at inhibiting protein aggregation, they can still exert neuroprotective effects by other, as yet unidentified, manners; e.g. by maintaining the proper cellular redox state or/and by preventing the activation of the apoptotic cascade. Here, we will focus our attention on how the differences in the activities of the HSPB proteins can influence neurodegenerative and neuromuscular disorders characterized by accumulation of aggregate-prone proteins. Understanding their mechanism of action may allow us to target a specific member in a specific cell type/disease for therapeutic purposes.
2013
368
1
13
Different anti-aggregation and pro-degradative functions of the members of the mammalian sHSP family in neurological disorders / Carra, Serena; Rusmini, P; Crippa, V; Giorgetti, E; Boncoraglio, A; Cristofani, R; Naujock, M; Meister, M; Minoia, M; Kampinga, Hh; Poletti, A.. - In: PHILOSOPHICAL TRANSACTIONS - ROYAL SOCIETY. BIOLOGICAL SCIENCES. - ISSN 0962-8436. - ELETTRONICO. - 368:(2013), pp. 1-13. [10.1098/rstb.2011.0409]
Carra, Serena; Rusmini, P; Crippa, V; Giorgetti, E; Boncoraglio, A; Cristofani, R; Naujock, M; Meister, M; Minoia, M; Kampinga, Hh; Poletti, A.
File in questo prodotto:
File Dimensione Formato  
Carra et al Phil Trans R. Soc. B 368 (2013).pdf

Open access

Tipologia: Versione pubblicata dall'editore
Dimensione 724.97 kB
Formato Adobe PDF
724.97 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/959895
Citazioni
  • ???jsp.display-item.citation.pmc??? 41
  • Scopus 66
  • ???jsp.display-item.citation.isi??? 62
social impact